Use of treatment pathway improves neoadjuvant chemotherapy use in muscle-invasive bladder cancer

Kassem S. Faraj, Anojan K. Navaratnam, Sarah Eversman, Laila Elias, Amit Syal, Mark D. Tyson, Erik P. Castle

Research output: Contribution to journalArticlepeer-review


Purpose: To assess the trends of neoadjuvant chemotherapy (NAC) use since its introduction in our practice pathway in patients with cT2 + bladder cancer over a 20-year period. Methods: This is a retrospective review of patients with cT2 + bladder cancer who underwent RC between 01/01/1998 and 01/01/2018 that aimed to evaluate the trends of NAC use and associated after implementation of a multidisciplinary treatment pathway. Cohorts were stratified into eras: pre-NAC (1998–2007) to NAC eras (2008–2018). Univariate analysis was conducted using Chi-squared test and Kaplan–Meier estimates were used to evaluate survival. Results: In 904 total patients who underwent RC, there were 493 with cT2 + UCC disease. The rate of NAC peaked at 84.2% in the most recent year of analysis in all patients and was 100% in cT2 + patients eligible for NAC. There was an increased rate of complete response (downstage to pT0) from 8.7% to 15.8% (p = 0.018) between the two eras. Unadjusted survival analysis revealed improved overall survival (OS) between eras with 5-year OS 53.2% vs. 42.7% and 10-year OS 42.7% vs. 26.4% in the NAC vs. pre-NAC cohorts, respectively (p = 0.016). Conclusions: In this review of 20 years of experience, we report a dramatic rise in the use of NAC after adoption of a multidisciplinary pathway that is associated with expected survival benefits.

Original languageEnglish (US)
Pages (from-to)1111-1118
Number of pages8
JournalInternational Urology and Nephrology
Issue number6
StatePublished - Jun 2021


  • Bladder cancer
  • Cystectomy
  • Muscle-invasive bladder cancer
  • Neoadjuvant chemotherapy

ASJC Scopus subject areas

  • Nephrology
  • Urology


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