Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium

ARTFL/LEFFTDS consortium

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Behavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR® plus NACC FTLD). Methods: We analyzed the CDR® plus NACC FTLD among participants from the baseline visit of the Advancing Research and Treatment for Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Consortium. Results: The CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB) = 0. The CDR®-SB was not sensitive, particularly in participants with mild nonfluent/agrammatic primary progressive aphasia. Participants with familial and sporadic behavioral variant FTD exhibited similar CDR® plus NACC FTLD profiles except that language impairment was more frequent in participants with mild sporadic behavioral variant FTD. Adding the BEHAV and/or LANG domains to the CDR®-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders. Discussion: The BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Frontotemporal Lobar Degeneration
Dementia
Language
Personality
Primary Progressive Nonfluent Aphasia
Frontotemporal Dementia

Keywords

  • Behavior
  • CDR®
  • Comportment and personality
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Language
  • NACC FTLD Module
  • Primary progressive aphasia

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Use of the CDR® plus NACC FTLD in mild FTLD : Data from the ARTFL/LEFFTDS consortium. / ARTFL/LEFFTDS consortium.

In: Alzheimer's and Dementia, 01.01.2019.

Research output: Contribution to journalArticle

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title = "Use of the CDR{\circledR} plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium",
abstract = "Introduction: Behavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR{\circledR}) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR{\circledR} plus NACC FTLD). Methods: We analyzed the CDR{\circledR} plus NACC FTLD among participants from the baseline visit of the Advancing Research and Treatment for Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Consortium. Results: The CDR{\circledR} plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR{\circledR} sum of boxes (CDR{\circledR}-SB) = 0. The CDR{\circledR}-SB was not sensitive, particularly in participants with mild nonfluent/agrammatic primary progressive aphasia. Participants with familial and sporadic behavioral variant FTD exhibited similar CDR{\circledR} plus NACC FTLD profiles except that language impairment was more frequent in participants with mild sporadic behavioral variant FTD. Adding the BEHAV and/or LANG domains to the CDR{\circledR}-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders. Discussion: The BEHAV and LANG domains enable the CDR{\circledR} plus NACC FTLD to capture early symptomatology of FTLD.",
keywords = "Behavior, CDR{\circledR}, Comportment and personality, Frontotemporal dementia, Frontotemporal lobar degeneration, Language, NACC FTLD Module, Primary progressive aphasia",
author = "{ARTFL/LEFFTDS consortium} and Toji Miyagawa and Danielle Brushaber and Jeremy Syrjanen and Walter Kremers and Julie Fields and Forsberg, {Leah K.} and Heuer, {Hilary W.} and David Knopman and John Kornak and Adam Boxer and Howie Rosen and Bradley Boeve and Brian Appleby and Yvette Bordelon and Jessica Bove and Patrick Brannelly and Christina Caso and Giovanni Coppola and Reilly Dever and Christina Dheel and Bradford Dickerson and Susan Dickinson and Sophia Dominguez and Kimiko Domoto-Reilly and Kelley Faber and Jessica Ferrell and Ann Fishman and Jamie Fong and Tatiana Foroud and Ralitza Gavrilova and Debra Gearhart and Behnaz Ghazanfari and Nupur Ghoshal and Goldman, {Jill S.} and Jonathan Graff-Radford and Neill Graff-Radford and Ian Grant and Murray Grossman and Dana Haley and Robin Hsiung and Edward Huey and David Irwin and David Jones and Lynne Jones and Kejal Kantarci and Anna Karydas and Daniel Kaufer and Leonard Petrucelli and Rosa Rademakers and Zbigniew Wszolek",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jalz.2019.05.013",
language = "English (US)",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",

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AU - ARTFL/LEFFTDS consortium

AU - Miyagawa, Toji

AU - Brushaber, Danielle

AU - Syrjanen, Jeremy

AU - Kremers, Walter

AU - Fields, Julie

AU - Forsberg, Leah K.

AU - Heuer, Hilary W.

AU - Knopman, David

AU - Kornak, John

AU - Boxer, Adam

AU - Rosen, Howie

AU - Boeve, Bradley

AU - Appleby, Brian

AU - Bordelon, Yvette

AU - Bove, Jessica

AU - Brannelly, Patrick

AU - Caso, Christina

AU - Coppola, Giovanni

AU - Dever, Reilly

AU - Dheel, Christina

AU - Dickerson, Bradford

AU - Dickinson, Susan

AU - Dominguez, Sophia

AU - Domoto-Reilly, Kimiko

AU - Faber, Kelley

AU - Ferrell, Jessica

AU - Fishman, Ann

AU - Fong, Jamie

AU - Foroud, Tatiana

AU - Gavrilova, Ralitza

AU - Gearhart, Debra

AU - Ghazanfari, Behnaz

AU - Ghoshal, Nupur

AU - Goldman, Jill S.

AU - Graff-Radford, Jonathan

AU - Graff-Radford, Neill

AU - Grant, Ian

AU - Grossman, Murray

AU - Haley, Dana

AU - Hsiung, Robin

AU - Huey, Edward

AU - Irwin, David

AU - Jones, David

AU - Jones, Lynne

AU - Kantarci, Kejal

AU - Karydas, Anna

AU - Kaufer, Daniel

AU - Petrucelli, Leonard

AU - Rademakers, Rosa

AU - Wszolek, Zbigniew

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Introduction: Behavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR® plus NACC FTLD). Methods: We analyzed the CDR® plus NACC FTLD among participants from the baseline visit of the Advancing Research and Treatment for Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Consortium. Results: The CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB) = 0. The CDR®-SB was not sensitive, particularly in participants with mild nonfluent/agrammatic primary progressive aphasia. Participants with familial and sporadic behavioral variant FTD exhibited similar CDR® plus NACC FTLD profiles except that language impairment was more frequent in participants with mild sporadic behavioral variant FTD. Adding the BEHAV and/or LANG domains to the CDR®-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders. Discussion: The BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.

AB - Introduction: Behavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR® plus NACC FTLD). Methods: We analyzed the CDR® plus NACC FTLD among participants from the baseline visit of the Advancing Research and Treatment for Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Consortium. Results: The CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB) = 0. The CDR®-SB was not sensitive, particularly in participants with mild nonfluent/agrammatic primary progressive aphasia. Participants with familial and sporadic behavioral variant FTD exhibited similar CDR® plus NACC FTLD profiles except that language impairment was more frequent in participants with mild sporadic behavioral variant FTD. Adding the BEHAV and/or LANG domains to the CDR®-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders. Discussion: The BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.

KW - Behavior

KW - CDR®

KW - Comportment and personality

KW - Frontotemporal dementia

KW - Frontotemporal lobar degeneration

KW - Language

KW - NACC FTLD Module

KW - Primary progressive aphasia

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U2 - 10.1016/j.jalz.2019.05.013

DO - 10.1016/j.jalz.2019.05.013

M3 - Article

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JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

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