Use of noninvasive gas exchange to track pulmonary vascular responses to exercise in heart failure

We determined whether a non-invasive gas exchange based estimate of pulmonary vascular (PV) capacitance [PV_CAP = stroke volume (SV) × pulmonary arterial pressure (Ppa)] (GX_CAP) tracked the PV response to exercise in heart-failure (HF) patients. Pulmonary wedge pressure (Ppw), Ppa, PV resistance (PVR), and gas exchange were measured simultaneously during cycle exercise in 42 HF patients undergoing right-heart catheterization. During exercise, P_ETCO₂ and V_E/VCO₂ were related to each other (r = -0.93, P < 0.01) and similarly related to mean Ppa (mPpa) (r = -0.39 and 0.36; P < 0.05); P_ETCO₂ was subsequently used as a metric of mPpa. Oxygen pulse (O₂ pulse) tracked the SV response to exercise (r = 0.91, P < 0.01). Thus, GX_CAP was calculated as O₂ pulse × P_ETCO₂. During exercise, invasively determined PV_CAP and non-invasive GX_CAP were related (r = 0.86, P < 0.01), and GX_CAP correlated with mPpa and PVR (r = -0.46 and -0.54; P < 0.01). In conclusion, noninvasive gas exchange measures may represent a simple way to track the PV response to exercise in HF.