Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus

Masayuki Shimojima, Takayuki Miyazawa, Yasuhiro Ikeda, Elizabeth L. McMonagle, Hayley Haining, Hiroomi Akashi, Yasuhiro Takeuchi, Margaret J. Hosie, Brian J. Willett

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.

Original languageEnglish (US)
Pages (from-to)1192-1195
Number of pages4
JournalScience
Volume303
Issue number5661
DOIs
StatePublished - Feb 20 2004

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus'. Together they form a unique fingerprint.

  • Cite this

    Shimojima, M., Miyazawa, T., Ikeda, Y., McMonagle, E. L., Haining, H., Akashi, H., Takeuchi, Y., Hosie, M. J., & Willett, B. J. (2004). Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus. Science, 303(5661), 1192-1195. https://doi.org/10.1126/science.1092124