TY - JOUR
T1 - Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus
AU - Shimojima, Masayuki
AU - Miyazawa, Takayuki
AU - Ikeda, Yasuhiro
AU - McMonagle, Elizabeth L.
AU - Haining, Hayley
AU - Akashi, Hiroomi
AU - Takeuchi, Yasuhiro
AU - Hosie, Margaret J.
AU - Willett, Brian J.
PY - 2004/2/20
Y1 - 2004/2/20
N2 - Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.
AB - Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.
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U2 - 10.1126/science.1092124
DO - 10.1126/science.1092124
M3 - Article
C2 - 14976315
AN - SCOPUS:1242351765
SN - 0036-8075
VL - 303
SP - 1192
EP - 1195
JO - Science
JF - Science
IS - 5661
ER -