Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus

Masayuki Shimojima, Takayuki Miyazawa, Yasuhiro H Ikeda, Elizabeth L. McMonagle, Hayley Haining, Hiroomi Akashi, Yasuhiro Takeuchi, Margaret J. Hosie, Brian J. Willett

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.

Original languageEnglish (US)
Pages (from-to)1192-1195
Number of pages4
JournalScience
Volume303
Issue number5661
DOIs
StatePublished - Feb 20 2004
Externally publishedYes

Fingerprint

Feline Immunodeficiency Virus
Feline Lentiviruses
Infection
CD27 Antigens
HIV
Virus Receptors
Giant Cells
Acquired Immunodeficiency Syndrome
Cats
Viruses

ASJC Scopus subject areas

  • General

Cite this

Shimojima, M., Miyazawa, T., Ikeda, Y. H., McMonagle, E. L., Haining, H., Akashi, H., ... Willett, B. J. (2004). Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus. Science, 303(5661), 1192-1195. https://doi.org/10.1126/science.1092124

Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus. / Shimojima, Masayuki; Miyazawa, Takayuki; Ikeda, Yasuhiro H; McMonagle, Elizabeth L.; Haining, Hayley; Akashi, Hiroomi; Takeuchi, Yasuhiro; Hosie, Margaret J.; Willett, Brian J.

In: Science, Vol. 303, No. 5661, 20.02.2004, p. 1192-1195.

Research output: Contribution to journalArticle

Shimojima, M, Miyazawa, T, Ikeda, YH, McMonagle, EL, Haining, H, Akashi, H, Takeuchi, Y, Hosie, MJ & Willett, BJ 2004, 'Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus', Science, vol. 303, no. 5661, pp. 1192-1195. https://doi.org/10.1126/science.1092124
Shimojima M, Miyazawa T, Ikeda YH, McMonagle EL, Haining H, Akashi H et al. Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus. Science. 2004 Feb 20;303(5661):1192-1195. https://doi.org/10.1126/science.1092124
Shimojima, Masayuki ; Miyazawa, Takayuki ; Ikeda, Yasuhiro H ; McMonagle, Elizabeth L. ; Haining, Hayley ; Akashi, Hiroomi ; Takeuchi, Yasuhiro ; Hosie, Margaret J. ; Willett, Brian J. / Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus. In: Science. 2004 ; Vol. 303, No. 5661. pp. 1192-1195.
@article{ab3b5baf91dd4a89be26d762a1ac156b,
title = "Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus",
abstract = "Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.",
author = "Masayuki Shimojima and Takayuki Miyazawa and Ikeda, {Yasuhiro H} and McMonagle, {Elizabeth L.} and Hayley Haining and Hiroomi Akashi and Yasuhiro Takeuchi and Hosie, {Margaret J.} and Willett, {Brian J.}",
year = "2004",
month = "2",
day = "20",
doi = "10.1126/science.1092124",
language = "English (US)",
volume = "303",
pages = "1192--1195",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5661",

}

TY - JOUR

T1 - Use of CD134 As a Primary Receptor by the Feline Immunodeficiency Virus

AU - Shimojima, Masayuki

AU - Miyazawa, Takayuki

AU - Ikeda, Yasuhiro H

AU - McMonagle, Elizabeth L.

AU - Haining, Hayley

AU - Akashi, Hiroomi

AU - Takeuchi, Yasuhiro

AU - Hosie, Margaret J.

AU - Willett, Brian J.

PY - 2004/2/20

Y1 - 2004/2/20

N2 - Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.

AB - Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor. We identified a primary receptor for FIV as CD134 (OX40), a T cell activation antigen and costimulatory molecule. CD134 expression promotes viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Infection is CXCR4-dependent, analogous to infection with X4 strains of HIV. Thus, despite the evolutionary divergence of the feline and human lentiviruses, both viruses use receptors that target the virus to a subset of cells that are pivotal to the acquired immune response.

UR - http://www.scopus.com/inward/record.url?scp=1242351765&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242351765&partnerID=8YFLogxK

U2 - 10.1126/science.1092124

DO - 10.1126/science.1092124

M3 - Article

VL - 303

SP - 1192

EP - 1195

JO - Science

JF - Science

SN - 0036-8075

IS - 5661

ER -