Use-dependent effects of lidocaine on the upper limit of vulnerability in open chest dogs

Yong Mei Cha, Barry B. Peters, Peng Sheng Chen

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Abstract

Objectives. This study was performed to test the hypothesis that sodium channel activity is important in determining ventricular vulnerability to electric shocks. Background. It is unknown whether sodium channel activity determines the upper limit of vulnerability. Methods. The ventricles of 10 open chest dogs were paced at 300-, 500-, or 1,000-ms cycle lengths. The shock strength associated with a 50% probability of reaching the upper limit of vulnerability (ULV50) and the shock strength associated with a 50% probability of defibrillation (DFT50) were then determined by means of an up-down algorithm. Lidocaine (9.2-mg/kg body weight loading dose and 285-μg/kg per min maintenance dose) was then given, and the ULV50 and the DFT50 were redetermined after 1 h of stable infusion. Results. The mean (±SD) lidocaine concentration was 11.9 ±2.4 μg/ml. At baseline, the ULV50 tested with each S1 cycle length was not significantly different from the DFT50. During lidocaine infusion, the ULV50 determined with cycle lengths of 300 and 500 ms (18.9 ± 11.3 and 16.1 ± 8.9 J, respectively) were significantly (p < 0.05) higher than those simultaneously determined for the DFT50 (11.2 ± 4.1 and 10.9 ± 5.6 J, respectively). However, when determined with an S1 cycle length of 1,000 ms, the ULV50 (10.4 ± 4.1 J) was not found to be significantly different from the DFT50 (10.3 ± 5.3 J). Lidocaine infusion increased (p < 0.05) QRS duration and the effective refractory periods for cycle lengths of 300 and 500 ms but not 1,000 ms. Conclusions. The effect of lidocaine on the upper limit of vulnerability is use dependent. These results are compatible with the hypothesis that sodium enamel activity is important in determining ventricular vulnerability to electrical shocks.

Original languageEnglish (US)
Pages (from-to)1688-1692
Number of pages5
JournalJournal of the American College of Cardiology
Volume23
Issue number7
DOIs
StatePublished - Jun 1994

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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