Urine-based assays for the detection of bladder cancer

Patrick Villicana, Bryant Whifting, Steve Goodison, Charles J. Rosser

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Bladder cancer is one of the most prevalent cancers worldwide. Furthermore, nonmuscle invasive bladder cancer has a 70% rate of recurrence, making it a considerable strain to the healthcare system. Patients with bladder cancer require repeat cystoscopic examinations of the bladder to monitor for tumor recurrence. The reason these patients have to undergo these costly, painful, invasive procedures is owing to the absence of accurate urine-based assays to detect the presence of bladder cancer noninvasively. Consequently, the development of a urine-based test to detect bladder cancer would be of tremendous benefit to both patients and healthcare systems. This article reports some of the more prominent urine markers in use-today. In addition, the article will highlight some new technologies that are used to investigate novel urinary markers.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalBiomarkers in Medicine
Volume3
Issue number3
DOIs
StatePublished - Aug 6 2009

Keywords

  • Bladder cancer
  • Genomics
  • Marker
  • NMP 22
  • Proteomics
  • Urinary cytology
  • Urine

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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