Urinary oxalate and glycolate excretion patterns in the first year of life: A longitudinal study

Bruce Z. Morgenstern, Dawn S. Milliner, Mary E. Murphy, Patricia S. Simmons, Thomas P. Moyer, David M. Wilson, Lynwood H. Smith

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

To determine the range of normal values, we studied urinary excretion of oxalate and glycolate prospectively and longitudinally in a cohort of 30 healthy term infants. Random urine samples were obtained at 2 days, 2 weeks, and 2, 4, 6, and 9 months of age. The results had a log-normal distribution. The mean oxalate/cretinine ratio, as determined by the oxalate oxidasee method, was 0.08 (in milligrams of oxalate to milligrams of creatinine) with a normalized range of 0.02 to 0.31. The mean ratio when oxalates were measured by using the Olthuis assay was 0.13 (range 0.03 to 0.53). The mean glycolate/creatinine ratio was 0.07 (range 0.02 to 0.26). These values did not correlate with increasing age. The oxalate/creatinine ratios were higher in formula-fed infants than in those who were fed human milk (0.14±0.16 vs 0.08±0.04; p<0.01).

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalThe Journal of Pediatrics
Volume123
Issue number2
DOIs
StatePublished - Aug 1993

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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