Urinary oxalate and glycolate excretion patterns in the first year of life: A longitudinal study

Bruce Z. Morgenstern, Dawn S. Milliner, Mary E. Murphy, Patricia S. Simmons, Thomas P. Moyer, David M. Wilson, Lynwood H. Smith

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Abstract

To determine the range of normal values, we studied urinary excretion of oxalate and glycolate prospectively and longitudinally in a cohort of 30 healthy term infants. Random urine samples were obtained at 2 days, 2 weeks, and 2, 4, 6, and 9 months of age. The results had a log-normal distribution. The mean oxalate/cretinine ratio, as determined by the oxalate oxidasee method, was 0.08 (in milligrams of oxalate to milligrams of creatinine) with a normalized range of 0.02 to 0.31. The mean ratio when oxalates were measured by using the Olthuis assay was 0.13 (range 0.03 to 0.53). The mean glycolate/creatinine ratio was 0.07 (range 0.02 to 0.26). These values did not correlate with increasing age. The oxalate/creatinine ratios were higher in formula-fed infants than in those who were fed human milk (0.14±0.16 vs 0.08±0.04; p<0.01).

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalThe Journal of Pediatrics
Volume123
Issue number2
DOIs
StatePublished - 1993

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glycolic acid
Oxalates
Longitudinal Studies
Creatinine
Infant Formula
Normal Distribution
Human Milk
Reference Values
Urine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Morgenstern, B. Z., Milliner, D. S., Murphy, M. E., Simmons, P. S., Moyer, T. P., Wilson, D. M., & Smith, L. H. (1993). Urinary oxalate and glycolate excretion patterns in the first year of life: A longitudinal study. The Journal of Pediatrics, 123(2), 248-251. https://doi.org/10.1016/S0022-3476(05)81696-8

Urinary oxalate and glycolate excretion patterns in the first year of life : A longitudinal study. / Morgenstern, Bruce Z.; Milliner, Dawn S.; Murphy, Mary E.; Simmons, Patricia S.; Moyer, Thomas P.; Wilson, David M.; Smith, Lynwood H.

In: The Journal of Pediatrics, Vol. 123, No. 2, 1993, p. 248-251.

Research output: Contribution to journalArticle

Morgenstern, BZ, Milliner, DS, Murphy, ME, Simmons, PS, Moyer, TP, Wilson, DM & Smith, LH 1993, 'Urinary oxalate and glycolate excretion patterns in the first year of life: A longitudinal study', The Journal of Pediatrics, vol. 123, no. 2, pp. 248-251. https://doi.org/10.1016/S0022-3476(05)81696-8
Morgenstern, Bruce Z. ; Milliner, Dawn S. ; Murphy, Mary E. ; Simmons, Patricia S. ; Moyer, Thomas P. ; Wilson, David M. ; Smith, Lynwood H. / Urinary oxalate and glycolate excretion patterns in the first year of life : A longitudinal study. In: The Journal of Pediatrics. 1993 ; Vol. 123, No. 2. pp. 248-251.
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