TY - JOUR
T1 - Urinary oxalate and glycolate excretion patterns in the first year of life
T2 - A longitudinal study
AU - Morgenstern, Bruce Z.
AU - Milliner, Dawn S.
AU - Murphy, Mary E.
AU - Simmons, Patricia S.
AU - Moyer, Thomas P.
AU - Wilson, David M.
AU - Smith, Lynwood H.
PY - 1993/8
Y1 - 1993/8
N2 - To determine the range of normal values, we studied urinary excretion of oxalate and glycolate prospectively and longitudinally in a cohort of 30 healthy term infants. Random urine samples were obtained at 2 days, 2 weeks, and 2, 4, 6, and 9 months of age. The results had a log-normal distribution. The mean oxalate/cretinine ratio, as determined by the oxalate oxidasee method, was 0.08 (in milligrams of oxalate to milligrams of creatinine) with a normalized range of 0.02 to 0.31. The mean ratio when oxalates were measured by using the Olthuis assay was 0.13 (range 0.03 to 0.53). The mean glycolate/creatinine ratio was 0.07 (range 0.02 to 0.26). These values did not correlate with increasing age. The oxalate/creatinine ratios were higher in formula-fed infants than in those who were fed human milk (0.14±0.16 vs 0.08±0.04; p<0.01).
AB - To determine the range of normal values, we studied urinary excretion of oxalate and glycolate prospectively and longitudinally in a cohort of 30 healthy term infants. Random urine samples were obtained at 2 days, 2 weeks, and 2, 4, 6, and 9 months of age. The results had a log-normal distribution. The mean oxalate/cretinine ratio, as determined by the oxalate oxidasee method, was 0.08 (in milligrams of oxalate to milligrams of creatinine) with a normalized range of 0.02 to 0.31. The mean ratio when oxalates were measured by using the Olthuis assay was 0.13 (range 0.03 to 0.53). The mean glycolate/creatinine ratio was 0.07 (range 0.02 to 0.26). These values did not correlate with increasing age. The oxalate/creatinine ratios were higher in formula-fed infants than in those who were fed human milk (0.14±0.16 vs 0.08±0.04; p<0.01).
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U2 - 10.1016/S0022-3476(05)81696-8
DO - 10.1016/S0022-3476(05)81696-8
M3 - Article
C2 - 8345420
AN - SCOPUS:0027185421
SN - 0022-3476
VL - 123
SP - 248
EP - 251
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 2
ER -