Urinary extracellular vesicles as biomarkers of kidney disease: From diagnostics to therapeutics

In O. Sun, Lilach O. Lerman

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Cell-derived extracellular vesicles (EVs) can be isolated from various body fluids, including urine. Urinary EVs have gained important recognition as potential diagnostic biomarkers in renal disease since their cargo includes nucleic acids, proteins, and other cellular components, which likely mirror the physiological and possibly pathophysiological state of cells along the nephron. Accumulating evidence highlights the feasibility of using EVs as biomarkers for diagnostic, prognostic, and therapeutic purposes in several forms of renal disease, such as acute kidney injury, glomerulonephritis, and renal transplantation. Additionally, exogenous delivery of EVs released in vitro by cells in culture may have salutary benefits for renal diseases. In this review, we introduce recent studies that attempt to identify urinary EVs as candidate biomarkers for human kidney diseases and consider their potential implication as a therapeutic option in key kidney diseases.

Original languageEnglish (US)
Article numberdiagnostics10050311
JournalDiagnostics
Volume10
Issue number5
DOIs
StatePublished - May 1 2020

Keywords

  • Biomarkers
  • Exosomes
  • Kidney diseases
  • Urine

ASJC Scopus subject areas

  • Clinical Biochemistry

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