TY - JOUR
T1 - Urinary extracellular vesicles as biomarkers of kidney disease
T2 - From diagnostics to therapeutics
AU - Sun, In O.
AU - Lerman, Lilach O.
N1 - Publisher Copyright:
© 2020 by the authors.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Cell-derived extracellular vesicles (EVs) can be isolated from various body fluids, including urine. Urinary EVs have gained important recognition as potential diagnostic biomarkers in renal disease since their cargo includes nucleic acids, proteins, and other cellular components, which likely mirror the physiological and possibly pathophysiological state of cells along the nephron. Accumulating evidence highlights the feasibility of using EVs as biomarkers for diagnostic, prognostic, and therapeutic purposes in several forms of renal disease, such as acute kidney injury, glomerulonephritis, and renal transplantation. Additionally, exogenous delivery of EVs released in vitro by cells in culture may have salutary benefits for renal diseases. In this review, we introduce recent studies that attempt to identify urinary EVs as candidate biomarkers for human kidney diseases and consider their potential implication as a therapeutic option in key kidney diseases.
AB - Cell-derived extracellular vesicles (EVs) can be isolated from various body fluids, including urine. Urinary EVs have gained important recognition as potential diagnostic biomarkers in renal disease since their cargo includes nucleic acids, proteins, and other cellular components, which likely mirror the physiological and possibly pathophysiological state of cells along the nephron. Accumulating evidence highlights the feasibility of using EVs as biomarkers for diagnostic, prognostic, and therapeutic purposes in several forms of renal disease, such as acute kidney injury, glomerulonephritis, and renal transplantation. Additionally, exogenous delivery of EVs released in vitro by cells in culture may have salutary benefits for renal diseases. In this review, we introduce recent studies that attempt to identify urinary EVs as candidate biomarkers for human kidney diseases and consider their potential implication as a therapeutic option in key kidney diseases.
KW - Biomarkers
KW - Exosomes
KW - Kidney diseases
KW - Urine
UR - http://www.scopus.com/inward/record.url?scp=85084824234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85084824234&partnerID=8YFLogxK
U2 - 10.3390/diagnostics10050311
DO - 10.3390/diagnostics10050311
M3 - Review article
AN - SCOPUS:85084824234
SN - 2075-4418
VL - 10
JO - Diagnostics
JF - Diagnostics
IS - 5
M1 - diagnostics10050311
ER -