Update on the Management of Respiratory Manifestations of the Antineutrophil Cytoplasmic Antibodies-Associated Vasculitides

Gwen E. Thompson, Ulrich Specks

Research output: Contribution to journalReview article


Antibody-associated vasculitis comprises 3 small vessel vasculitis syndromes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic polyangiitis (EGPA). This article outlines the major tracheobronchial and pulmonary parenchymal disease manifestations of GPA and MPA and their management, as well as relevant recent advances in the treatment of EGPA. Shared trends in the management of all 3 syndromes are: (1) a focus on glucocorticoid avoidance and (2) an increasing reliance on biologic agents. Evidence from randomized controlled trials and large cohort studies in support of these trends as well as ongoing research efforts are summarized.

Original languageEnglish (US)
Pages (from-to)573-582
Number of pages10
JournalClinics in Chest Medicine
Issue number3
StatePublished - Sep 2019



  • ANCA
  • Alveolar hemorrhage
  • Antineutrophil cytoplasmic antibodies
  • Eosinophilic granulomatosis with polyangiitis
  • Granulomatosis with polyangiitis
  • Interstitial lung disease
  • Microscopic polyangiitis
  • Vasculitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this