Update on the differential diagnosis, surveillance and management of hereditary non-polyposis colorectal cancer

H. T. Lynch, Thomas Christopher Smyrk, J. Lynch, R. Fitzgibbons, S. Lanspa, T. McGinn

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Hereditary non-polyposis colorectal cancer (HNPCC) is the most common hereditary form of colorectal cancer (CRC), accounting for approximately 10% of the total CRC burden. HNPCC lacks premonitory physical stigmata, thereby making the family history crucial for diagnosis. Advances in molecular genetics during the past 2 years have led to the cloning of four HNPCC genes (MHS2, MLH1, PMS1 and PMS2). It is now possible to provide presymptomatic DNA testing followed by genetic counselling for gene carriers. Some studies have shown that adenomas in HNPCC are larger, more villous, and have more high grade dysplasia than sporadic cases, suggesting an accelerated adenoma-carcinoma sequence. Given the early age of onset and proximal predominance of CRC, we initiate colonoscopy at age 20-25 years and we recommend that it be performed every 1-2 years. The wealth of clinical and molecular genetic knowledge currently available to physicians about HNPCC can be used effectively for cancer control.

Original languageEnglish (US)
Pages (from-to)1039-1046
Number of pages8
JournalEuropean Journal of Cancer
Volume31
Issue number7-8
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Colorectal Neoplasms
Differential Diagnosis
Adenoma
Molecular Biology
Christianity
Neoplasm Genes
Genetic Counseling
Colonoscopy
Age of Onset
Organism Cloning
Carcinoma
Physicians
DNA
Genes
Neoplasms

Keywords

  • cancer genes
  • colon cancer
  • genetic counselling
  • genetics
  • HNPCC
  • surveillance

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Hematology

Cite this

Update on the differential diagnosis, surveillance and management of hereditary non-polyposis colorectal cancer. / Lynch, H. T.; Smyrk, Thomas Christopher; Lynch, J.; Fitzgibbons, R.; Lanspa, S.; McGinn, T.

In: European Journal of Cancer, Vol. 31, No. 7-8, 1995, p. 1039-1046.

Research output: Contribution to journalArticle

Lynch, H. T. ; Smyrk, Thomas Christopher ; Lynch, J. ; Fitzgibbons, R. ; Lanspa, S. ; McGinn, T. / Update on the differential diagnosis, surveillance and management of hereditary non-polyposis colorectal cancer. In: European Journal of Cancer. 1995 ; Vol. 31, No. 7-8. pp. 1039-1046.
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