TY - JOUR
T1 - Update on celiac disease - etiology, differential diagnosis, drug targets, and management advances
AU - Scanlon, Samantha A.
AU - Murray, Joseph A.
PY - 2011/12/17
Y1 - 2011/12/17
N2 - Celiac disease (CD) is an immune-mediated enteropathy triggered by exposure to wheat gluten and similar proteins found in rye and barley that affects genetically susceptible persons. This immune-mediated enteropathy is characterized by villous atrophy, intraepithelial lymphocytosis, and crypt hyperplasia. Once thought a disease that largely presented with malnourished children, the wide spectrum of disease activity is now better recognized and this has resulted in a shift in the presenting symptoms of most patients with CD. New advances in testing, both serologic and endoscopic, have dramatically increased the detection and diagnosis of CD. While the gluten-free diet is still the only treatment for CD, recent investigations have explored alternative approaches, including the use of altered nonimmunogenic wheat variants, enzymatic degradation of gluten, tissue transglutaminase inhibitors, induction of tolerance, and peptides to restore integrity to intestinal tight junctions.
AB - Celiac disease (CD) is an immune-mediated enteropathy triggered by exposure to wheat gluten and similar proteins found in rye and barley that affects genetically susceptible persons. This immune-mediated enteropathy is characterized by villous atrophy, intraepithelial lymphocytosis, and crypt hyperplasia. Once thought a disease that largely presented with malnourished children, the wide spectrum of disease activity is now better recognized and this has resulted in a shift in the presenting symptoms of most patients with CD. New advances in testing, both serologic and endoscopic, have dramatically increased the detection and diagnosis of CD. While the gluten-free diet is still the only treatment for CD, recent investigations have explored alternative approaches, including the use of altered nonimmunogenic wheat variants, enzymatic degradation of gluten, tissue transglutaminase inhibitors, induction of tolerance, and peptides to restore integrity to intestinal tight junctions.
KW - CD diagnosis
KW - Epidemiology
KW - Gliadin
KW - Gluten
KW - Immune-mediated enteropathy
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=84856192092&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856192092&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:84856192092
SN - 1178-7023
VL - 4
SP - 297
EP - 311
JO - Clinical and Experimental Gastroenterology
JF - Clinical and Experimental Gastroenterology
IS - 1
ER -