Update on celiac disease - etiology, differential diagnosis, drug targets, and management advances

Samantha A. Scanlon, Joseph A. Murray

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Celiac disease (CD) is an immune-mediated enteropathy triggered by exposure to wheat gluten and similar proteins found in rye and barley that affects genetically susceptible persons. This immune-mediated enteropathy is characterized by villous atrophy, intraepithelial lymphocytosis, and crypt hyperplasia. Once thought a disease that largely presented with malnourished children, the wide spectrum of disease activity is now better recognized and this has resulted in a shift in the presenting symptoms of most patients with CD. New advances in testing, both serologic and endoscopic, have dramatically increased the detection and diagnosis of CD. While the gluten-free diet is still the only treatment for CD, recent investigations have explored alternative approaches, including the use of altered nonimmunogenic wheat variants, enzymatic degradation of gluten, tissue transglutaminase inhibitors, induction of tolerance, and peptides to restore integrity to intestinal tight junctions.

Original languageEnglish (US)
Pages (from-to)297-311
Number of pages15
JournalClinical and Experimental Gastroenterology
Volume4
Issue number1
StatePublished - Dec 17 2011

Keywords

  • CD diagnosis
  • Epidemiology
  • Gliadin
  • Gluten
  • Immune-mediated enteropathy
  • Therapy

ASJC Scopus subject areas

  • Gastroenterology

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