Unsupervised Performance of the CogState Brief Battery in the Brain Health Registry: Implications for Detecting Cognitive Decline

T. Banh, C. Jin, J. Neuhaus, R. S. Mackin, P. Maruff, N. Stricker, M. W. Weiner, R. L. Nosheny

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: The feasibility and validity of unsupervised, longitudinal brief computerized cognitive batteries is unknown. Methods: Participants aged 56–90 (N = 19476) from the Brain Health Registry (BHR) completed the CogState Brief Battery (CBB) at 6-month intervals over a period of 5 years. We used linear mixed-effects models to assess whether cross-sectional and longitudinal performance on CBB within BHR was associated with demographic and cognitive characteristics. We also defined a group of CBB decliners based on subject-specific slopes and estimated associations between decliner status and participant characteristics. Results: We found weak associations between longitudinal change in CBB and participant characteristics. Cross-sectional CBB scores were significantly associated with participant characteristics such as age, gender, ethnicity, self-reported disease status, and memory concern. CBB decliners were more likely to self-report mild cognitive impairment (MCI) and memory concerns. Discussion: Cross-sectional, remote CBB shows evidence of construct validity, but our results suggest that longitudinal assessment may not provide additional value for identifying those at risk for and with cognitive impairment.

Original languageEnglish (US)
JournalThe journal of prevention of Alzheimer's disease
DOIs
StateAccepted/In press - 2021

Keywords

  • Brain Health Registry
  • Cognitive decline
  • neuropsychology

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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