Unlocking the Mysteries of Diastolic Function. Deciphering the Rosetta Stone 10 Years Later

Steven J. Lester, A. Jamil Tajik, Rick A. Nishimura, Jae K. Oh, Bijoy K. Khandheria, James B. Seward

Research output: Contribution to journalReview article

269 Scopus citations


It has now been a quarter of a century since the first description by Kitabatake and his associates of the use of echo-Doppler to characterize the transmitral flow velocity curves in various disease states. A decade ago we described the role of echocardiography in the "Evaluation of Diastolic Filling of Left Ventricle in Health and Disease: Doppler Echocardiography Is the Clinician's Rosetta Stone." Over the ensuing decade, advances in echo-Doppler have helped to further decipher the morphologic and physiological expression of cardiovascular disease and unlock additional mysteries of diastology. The purpose of this review is to highlight the developments in echo-Doppler and refinements in our knowledge that have occurred over the past decade that enhance our understanding of diastology.

Original languageEnglish (US)
Pages (from-to)679-689
Number of pages11
JournalJournal of the American College of Cardiology
Issue number7
StatePublished - Feb 19 2008


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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