Unilateral pallidotomy for Parkinson's disease: Speech, motor, and neuropsychological outcome measurements

R. J. Uitti; R. E. Wharen; J. R. Duffy; J. A. Lucas; S. L. Schneider; J. D. Rippeth; Z. K. Wszolek; A. A. Obwegeser; M. F. Turk; E. J. Atkinson

doi:10.1016/S1353-8020(00)00008-0

Unilateral pallidotomy for Parkinson's disease: Speech, motor, and neuropsychological outcome measurements

R. J. Uitti, R. E. Wharen, J. R. Duffy, J. A. Lucas, S. L. Schneider, J. D. Rippeth, Z. K. Wszolek, A. A. Obwegeser, M. F. Turk, E. J. Atkinson

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21 Scopus citations

Abstract

We studied the effects of unilateral medial pallidotomy in the first 57 consecutive Parkinson's disease (PD) patients undergoing this MRI/electrophysiologically guided procedure at our institution, obtaining qualitative and quantitative measures of speech, motor function, activities of daily living, and neuropsychological functioning at 3 and 12months post-operatively. Speech intelligibility was typically preserved, declining mildly in one-third of patients post-operatively. Pallidotomy significantly improved motor function similarly in patients ≥65 or <65years (n=20). Cognitive abilities generally remained stable following surgery; however, performance on measures of letter fluency and semantic fluency declined in patients with left pallidotomies. We conclude that in our series mild deterioration in speech may occur with unilateral pallidotomy in patients otherwise responsive to this treatment. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	133-143
Number of pages	11
Journal	Parkinsonism and Related Disorders
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/S1353-8020(00)00008-0
State	Published - Jul 2000

Keywords

Outcome measures
Pallidotomy
Parkinson's disease
Speech

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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title = "Unilateral pallidotomy for Parkinson's disease: Speech, motor, and neuropsychological outcome measurements",

abstract = "We studied the effects of unilateral medial pallidotomy in the first 57 consecutive Parkinson's disease (PD) patients undergoing this MRI/electrophysiologically guided procedure at our institution, obtaining qualitative and quantitative measures of speech, motor function, activities of daily living, and neuropsychological functioning at 3 and 12months post-operatively. Speech intelligibility was typically preserved, declining mildly in one-third of patients post-operatively. Pallidotomy significantly improved motor function similarly in patients ≥65 or <65years (n=20). Cognitive abilities generally remained stable following surgery; however, performance on measures of letter fluency and semantic fluency declined in patients with left pallidotomies. We conclude that in our series mild deterioration in speech may occur with unilateral pallidotomy in patients otherwise responsive to this treatment. Copyright (C) 2000 Elsevier Science Ltd.",

keywords = "Outcome measures, Pallidotomy, Parkinson's disease, Speech",

author = "Uitti, {R. J.} and Wharen, {R. E.} and Duffy, {J. R.} and Lucas, {J. A.} and Schneider, {S. L.} and Rippeth, {J. D.} and Wszolek, {Z. K.} and Obwegeser, {A. A.} and Turk, {M. F.} and Atkinson, {E. J.}",

note = "Funding Information: The authors wish to acknowledge Drs Charles Adler and John Caviness for their contribution of patients, Ms Lauren Makarov for her assistance in managing the neuropsychological database, and Ms Darlene Gunsolus, Claudia Pickering, and Debra McNally for their invaluable assistance in the preparation of this manuscript. This study was made possible by support from Mayo Foundation.",

year = "2000",

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doi = "10.1016/S1353-8020(00)00008-0",

language = "English (US)",

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AU - Uitti, R. J.

AU - Wharen, R. E.

AU - Duffy, J. R.

AU - Lucas, J. A.

AU - Schneider, S. L.

AU - Rippeth, J. D.

AU - Wszolek, Z. K.

AU - Obwegeser, A. A.

AU - Turk, M. F.

AU - Atkinson, E. J.

N1 - Funding Information: The authors wish to acknowledge Drs Charles Adler and John Caviness for their contribution of patients, Ms Lauren Makarov for her assistance in managing the neuropsychological database, and Ms Darlene Gunsolus, Claudia Pickering, and Debra McNally for their invaluable assistance in the preparation of this manuscript. This study was made possible by support from Mayo Foundation.

PY - 2000/7

Y1 - 2000/7

N2 - We studied the effects of unilateral medial pallidotomy in the first 57 consecutive Parkinson's disease (PD) patients undergoing this MRI/electrophysiologically guided procedure at our institution, obtaining qualitative and quantitative measures of speech, motor function, activities of daily living, and neuropsychological functioning at 3 and 12months post-operatively. Speech intelligibility was typically preserved, declining mildly in one-third of patients post-operatively. Pallidotomy significantly improved motor function similarly in patients ≥65 or <65years (n=20). Cognitive abilities generally remained stable following surgery; however, performance on measures of letter fluency and semantic fluency declined in patients with left pallidotomies. We conclude that in our series mild deterioration in speech may occur with unilateral pallidotomy in patients otherwise responsive to this treatment. Copyright (C) 2000 Elsevier Science Ltd.

AB - We studied the effects of unilateral medial pallidotomy in the first 57 consecutive Parkinson's disease (PD) patients undergoing this MRI/electrophysiologically guided procedure at our institution, obtaining qualitative and quantitative measures of speech, motor function, activities of daily living, and neuropsychological functioning at 3 and 12months post-operatively. Speech intelligibility was typically preserved, declining mildly in one-third of patients post-operatively. Pallidotomy significantly improved motor function similarly in patients ≥65 or <65years (n=20). Cognitive abilities generally remained stable following surgery; however, performance on measures of letter fluency and semantic fluency declined in patients with left pallidotomies. We conclude that in our series mild deterioration in speech may occur with unilateral pallidotomy in patients otherwise responsive to this treatment. Copyright (C) 2000 Elsevier Science Ltd.

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Unilateral pallidotomy for Parkinson's disease: Speech, motor, and neuropsychological outcome measurements

Abstract

Keywords

ASJC Scopus subject areas

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