Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

Hanyin Wang, Subhraleena Das, Patrick M. Wieruszewski, Jamil Taji, Brian Bartlett, Nabila Azad, Arnab Chowdhury, Gururaj J. Kolar, Nitesh Jain, Mir R. Subla, Syed Anjum Khan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.

Original languageEnglish (US)
Pages (from-to)e55-e58
JournalChest
Volume158
Issue number2
DOIs
StatePublished - Aug 2020

Keywords

  • COVID-19
  • SARS-CoV-2
  • angiotensin II
  • septic shock

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock'. Together they form a unique fingerprint.

Cite this