Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

Hanyin Wang; Subhraleena Das; Patrick M. Wieruszewski; Jamil Taji; Brian Bartlett; Nabila Azad; Arnab Chowdhury; Gururaj J. Kolar; Nitesh Jain; Mir R. Subla; Syed Anjum Khan

doi:10.1016/j.chest.2020.04.015

Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

Hanyin Wang, Subhraleena Das, Patrick M. Wieruszewski, Jamil Taji, Brian Bartlett, Nabila Azad, Arnab Chowdhury, Gururaj J. Kolar, Nitesh Jain, Mir R. Subla, Syed Anjum Khan

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.

Original language	English (US)
Pages (from-to)	e55-e58
Journal	Chest
Volume	158
Issue number	2
DOIs	https://doi.org/10.1016/j.chest.2020.04.015
State	Published - Aug 2020

Keywords

COVID-19
SARS-CoV-2
angiotensin II
septic shock

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.chest.2020.04.015

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title = "Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock",

abstract = "We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.",

keywords = "COVID-19, SARS-CoV-2, angiotensin II, septic shock",

author = "Hanyin Wang and Subhraleena Das and Wieruszewski, {Patrick M.} and Jamil Taji and Brian Bartlett and Nabila Azad and Arnab Chowdhury and Kolar, {Gururaj J.} and Nitesh Jain and Subla, {Mir R.} and Khan, {Syed Anjum}",

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year = "2020",

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doi = "10.1016/j.chest.2020.04.015",

language = "English (US)",

volume = "158",

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journal = "Chest",

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T1 - Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

AU - Wang, Hanyin

AU - Das, Subhraleena

AU - Wieruszewski, Patrick M.

AU - Taji, Jamil

AU - Bartlett, Brian

AU - Azad, Nabila

AU - Chowdhury, Arnab

AU - Kolar, Gururaj J.

AU - Jain, Nitesh

AU - Subla, Mir R.

AU - Khan, Syed Anjum

PY - 2020/8

Y1 - 2020/8

N2 - We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.

AB - We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.

KW - COVID-19

KW - SARS-CoV-2

KW - angiotensin II

KW - septic shock

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SP - e55-e58

JO - Chest

JF - Chest

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ER -

Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

Abstract

Keywords

ASJC Scopus subject areas

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