Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication

Tomasz Laskus, Marek Radkowski, Lian Fu Wang, Marek Nowicki, Jorge Rakela

Research output: Contribution to journalArticle

104 Scopus citations

Abstract

We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues in patients with chronic hepatitis C. These results are compatible with the existence of independent viral compartments in the infected host. Our results also suggest that PBMCs, and probably various tissues, can selectively adsorb viral subpopulations differing in the E2 region.

Original languageEnglish (US)
Pages (from-to)1014-1017
Number of pages4
JournalJournal of virology
Volume74
Issue number2
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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