Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication

Tomasz Laskus; Marek Radkowski; Lian Fu Wang; Marek Nowicki; Jorge Rakela

doi:10.1128/JVI.74.2.1014-1017.2000

Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication

Tomasz Laskus, Marek Radkowski, Lian Fu Wang, Marek Nowicki, Jorge Rakela

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues in patients with chronic hepatitis C. These results are compatible with the existence of independent viral compartments in the infected host. Our results also suggest that PBMCs, and probably various tissues, can selectively adsorb viral subpopulations differing in the E2 region.

Original language	English (US)
Pages (from-to)	1014-1017
Number of pages	4
Journal	Journal of virology
Volume	74
Issue number	2
DOIs	https://doi.org/10.1128/JVI.74.2.1014-1017.2000
State	Published - 2000

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

Access to Document

10.1128/JVI.74.2.1014-1017.2000

Fingerprint

Dive into the research topics of 'Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication'. Together they form a unique fingerprint.

Cite this

Laskus, T., Radkowski, M., Wang, L. F., Nowicki, M., & Rakela, J. (2000). Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication. Journal of virology, 74(2), 1014-1017. https://doi.org/10.1128/JVI.74.2.1014-1017.2000

Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication. / Laskus, Tomasz; Radkowski, Marek; Wang, Lian Fu et al.
In: Journal of virology, Vol. 74, No. 2, 2000, p. 1014-1017.

Research output: Contribution to journal › Article › peer-review

Laskus, T, Radkowski, M, Wang, LF, Nowicki, M & Rakela, J 2000, 'Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication', Journal of virology, vol. 74, no. 2, pp. 1014-1017. https://doi.org/10.1128/JVI.74.2.1014-1017.2000

@article{dc95eafa993a4e3a99842d62a724b113,

title = "Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication",

abstract = "We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues in patients with chronic hepatitis C. These results are compatible with the existence of independent viral compartments in the infected host. Our results also suggest that PBMCs, and probably various tissues, can selectively adsorb viral subpopulations differing in the E2 region.",

author = "Tomasz Laskus and Marek Radkowski and Wang, {Lian Fu} and Marek Nowicki and Jorge Rakela",

year = "2000",

doi = "10.1128/JVI.74.2.1014-1017.2000",

language = "English (US)",

volume = "74",

pages = "1014--1017",

journal = "Journal of virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "2",

}

TY - JOUR

T1 - Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease

T2 - Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication

AU - Laskus, Tomasz

AU - Radkowski, Marek

AU - Wang, Lian Fu

AU - Nowicki, Marek

AU - Rakela, Jorge

PY - 2000

Y1 - 2000

N2 - We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues in patients with chronic hepatitis C. These results are compatible with the existence of independent viral compartments in the infected host. Our results also suggest that PBMCs, and probably various tissues, can selectively adsorb viral subpopulations differing in the E2 region.

AB - We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues in patients with chronic hepatitis C. These results are compatible with the existence of independent viral compartments in the infected host. Our results also suggest that PBMCs, and probably various tissues, can selectively adsorb viral subpopulations differing in the E2 region.

UR - http://www.scopus.com/inward/record.url?scp=0033986062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033986062&partnerID=8YFLogxK

U2 - 10.1128/JVI.74.2.1014-1017.2000

DO - 10.1128/JVI.74.2.1014-1017.2000

M3 - Article

C2 - 10623766

AN - SCOPUS:0033986062

SN - 0022-538X

VL - 74

SP - 1014

EP - 1017

JO - Journal of virology

JF - Journal of virology

IS - 2

ER -

Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: Confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this