Type II Glycogenosis in Adults

George Hug, William K. Schubert, Shirley W. Soukup, Corrado Angelini, Andrew G Engel, Jack L. Titus

Research output: Contribution to journalLetter

5 Citations (Scopus)

Abstract

To the Editor: The classic form of Type II glycogenosis with death occurring in infancy or early childhood (infantile GSD II, or Pompe's disease) exhibits intracellular glycogen accumulations surrounded by membranes, so called “abnormal lysosomes”1,2 that may be explained by the deficiency of acid α-glucosidase.3 However, this lysosomal enzyme deficiency does not explain the excessive cytoplasmic glycogen observed in infantile GSD II2 and, to a lesser extent, in the adult form of the disease. In 22 patients of 13 families with GSD II, we did not encounter adult and infantile cases in different members of the same family. In infantile.

Original languageEnglish (US)
Pages (from-to)216-217
Number of pages2
JournalNew England Journal of Medicine
Volume288
Issue number4
DOIs
StatePublished - Jan 25 1973

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Glycogen Storage Disease Type II
Glycogen
Acids
Membranes
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hug, G., Schubert, W. K., Soukup, S. W., Angelini, C., Engel, A. G., & Titus, J. L. (1973). Type II Glycogenosis in Adults. New England Journal of Medicine, 288(4), 216-217. https://doi.org/10.1056/NEJM197301252880420

Type II Glycogenosis in Adults. / Hug, George; Schubert, William K.; Soukup, Shirley W.; Angelini, Corrado; Engel, Andrew G; Titus, Jack L.

In: New England Journal of Medicine, Vol. 288, No. 4, 25.01.1973, p. 216-217.

Research output: Contribution to journalLetter

Hug, G, Schubert, WK, Soukup, SW, Angelini, C, Engel, AG & Titus, JL 1973, 'Type II Glycogenosis in Adults', New England Journal of Medicine, vol. 288, no. 4, pp. 216-217. https://doi.org/10.1056/NEJM197301252880420
Hug G, Schubert WK, Soukup SW, Angelini C, Engel AG, Titus JL. Type II Glycogenosis in Adults. New England Journal of Medicine. 1973 Jan 25;288(4):216-217. https://doi.org/10.1056/NEJM197301252880420
Hug, George ; Schubert, William K. ; Soukup, Shirley W. ; Angelini, Corrado ; Engel, Andrew G ; Titus, Jack L. / Type II Glycogenosis in Adults. In: New England Journal of Medicine. 1973 ; Vol. 288, No. 4. pp. 216-217.
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