Type II Glycogenosis in Adults

George Hug, William K. Schubert, Shirley W. Soukup, Corrado Angelini, Andrew G. Engel, Jack L. Titus

Research output: Contribution to journalLetter

5 Scopus citations

Abstract

To the Editor: The classic form of Type II glycogenosis with death occurring in infancy or early childhood (infantile GSD II, or Pompe's disease) exhibits intracellular glycogen accumulations surrounded by membranes, so called “abnormal lysosomes”1,2 that may be explained by the deficiency of acid α-glucosidase.3 However, this lysosomal enzyme deficiency does not explain the excessive cytoplasmic glycogen observed in infantile GSD II2 and, to a lesser extent, in the adult form of the disease. In 22 patients of 13 families with GSD II, we did not encounter adult and infantile cases in different members of the same family. In infantile.

Original languageEnglish (US)
Pages (from-to)216-217
Number of pages2
JournalNew England Journal of Medicine
Volume288
Issue number4
DOIs
StatePublished - Jan 25 1973

ASJC Scopus subject areas

  • Medicine(all)

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    Hug, G., Schubert, W. K., Soukup, S. W., Angelini, C., Engel, A. G., & Titus, J. L. (1973). Type II Glycogenosis in Adults. New England Journal of Medicine, 288(4), 216-217. https://doi.org/10.1056/NEJM197301252880420