Abstract
Type II collagen from six mammalian species was investigated for the capacity to induce an immune response and collagen-induced arthritis (CIA) n C57/B10 congenic mouse strains. H-2(q) haplotype mice were susceptible to chick, bovine, deer, rat, and human type II collagen, but were resistant to arthritis induced by porcine type II collagen. H-2(r) haplotype mice only developed CIA in response to bovine, deer, and porcine collagen. High antibody responses in the absence of disease, directed against a specific type II collagen, were observed in many independent haplotypes. The cross-reactive capacity of different antisera to the various collagen species was studied. The data support the existence of two arthritogenic and multiple nonarthritogenic epitopes on the type II collagen molecule.
Original language | English (US) |
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Pages (from-to) | 2443-2451 |
Number of pages | 9 |
Journal | Journal of Immunology |
Volume | 135 |
Issue number | 4 |
State | Published - 1985 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology