TY - JOUR
T1 - Type D personality is associated with increased prevalence of ventricular arrhythmias in community-residing persons without coronary heart disease
AU - Einvik, Gunnar
AU - Dammen, Toril
AU - Namtvedt, Silje K.
AU - Hrubos-Strøm, Harald
AU - Randby, Anna
AU - Kristiansen, Håvard A.
AU - Nordhus, Inger H.
AU - Somers, Virend K.
AU - Omland, Torbjørn
N1 - Funding Information:
This work was supported by the South-Eastern Norway Regional Health Authority (grant number 2004219).
PY - 2014/5
Y1 - 2014/5
N2 - Background: Type D personality may be a risk factor for poor outcome in patients with cardiovascular disease. The biological mechanisms underlying this association are poorly understood. The objective of the study was to test the hypotheses that Type D personality is associated with biological markers for sympathetic dysregulation. Design: Cross-sectional community-based study. Methods: Type D personality was evaluated by DS-14 in 450 persons (46% men), aged between 30 and 65 years. From a Holter-recording, (mean length 18.3 hours), long-term heart rate, ventricular arrhythmias, and heart rate variability (HRV) were registered as markers of sympathetic dysregulation. Traditional cardiovascular risk factors, apnoea- hypopnoea index, medication, and anxiety symptoms were adjusted for. Results: Type D persons had higher long-term averaged heart rate (74 vs. 71 beats/min, p=0.003), but this difference was attenuated and not significant in the multivariate model (p=0.078)). There was an increased prevalence of complex ventricular ectopy (bigeminy, trigeminy, or non-sustained ventricular tachycardia; 14 vs. 6%, p=0.005 in multivariate model). HRV indices did not differ significantly between those with or without Type D personality. Anxiety symptoms did not confound these associations. Conclusions: Type D personality is independently associated with a higher likelihood of ventricular arrhythmias, which may be implicated in the increased cardiovascular risk observed in persons with Type D personality.
AB - Background: Type D personality may be a risk factor for poor outcome in patients with cardiovascular disease. The biological mechanisms underlying this association are poorly understood. The objective of the study was to test the hypotheses that Type D personality is associated with biological markers for sympathetic dysregulation. Design: Cross-sectional community-based study. Methods: Type D personality was evaluated by DS-14 in 450 persons (46% men), aged between 30 and 65 years. From a Holter-recording, (mean length 18.3 hours), long-term heart rate, ventricular arrhythmias, and heart rate variability (HRV) were registered as markers of sympathetic dysregulation. Traditional cardiovascular risk factors, apnoea- hypopnoea index, medication, and anxiety symptoms were adjusted for. Results: Type D persons had higher long-term averaged heart rate (74 vs. 71 beats/min, p=0.003), but this difference was attenuated and not significant in the multivariate model (p=0.078)). There was an increased prevalence of complex ventricular ectopy (bigeminy, trigeminy, or non-sustained ventricular tachycardia; 14 vs. 6%, p=0.005 in multivariate model). HRV indices did not differ significantly between those with or without Type D personality. Anxiety symptoms did not confound these associations. Conclusions: Type D personality is independently associated with a higher likelihood of ventricular arrhythmias, which may be implicated in the increased cardiovascular risk observed in persons with Type D personality.
KW - Anxiety
KW - Type D personality
KW - heart rate variability
KW - ventricular arrhythmia
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U2 - 10.1177/2047487312462800
DO - 10.1177/2047487312462800
M3 - Article
C2 - 23008135
AN - SCOPUS:84900440471
SN - 2047-4873
VL - 21
SP - 592
EP - 600
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 5
ER -