Twenty-First Century Precision Medicine in Oncology: Genomic Profiling in Patients With Cancer

Mitesh J. Borad; Patricia M. LoRusso

doi:10.1016/j.mayocp.2017.08.002

Twenty-First Century Precision Medicine in Oncology: Genomic Profiling in Patients With Cancer

Mitesh J. Borad, Patricia M. LoRusso

Hematology/Oncology

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

The advent of next-generation sequencing has accelerated the implementation of genomic profiling in the care and management of patients with cancer. Initial efforts have focused on target identification in patients with advanced cancer. Prognostication, resistance detection, disease monitoring, and early detection efforts are also underway. This review highlights some of the challenges in this evolving space. This includes choosing between gene-panel and comprehensive approaches, DNA and transcriptome data integration, reduction of false-positive variants, addressing tumor heterogeneity, establishment of workflows to address unsolicited findings, and data sharing and privacy concerns.

Original language	English (US)
Pages (from-to)	1583-1591
Number of pages	9
Journal	Mayo Clinic proceedings
Volume	92
Issue number	10
DOIs	https://doi.org/10.1016/j.mayocp.2017.08.002
State	Published - Oct 2017

ASJC Scopus subject areas

General Medicine

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10.1016/j.mayocp.2017.08.002

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title = "Twenty-First Century Precision Medicine in Oncology: Genomic Profiling in Patients With Cancer",

abstract = "The advent of next-generation sequencing has accelerated the implementation of genomic profiling in the care and management of patients with cancer. Initial efforts have focused on target identification in patients with advanced cancer. Prognostication, resistance detection, disease monitoring, and early detection efforts are also underway. This review highlights some of the challenges in this evolving space. This includes choosing between gene-panel and comprehensive approaches, DNA and transcriptome data integration, reduction of false-positive variants, addressing tumor heterogeneity, establishment of workflows to address unsolicited findings, and data sharing and privacy concerns.",

author = "Borad, {Mitesh J.} and LoRusso, {Patricia M.}",

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year = "2017",

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AU - LoRusso, Patricia M.

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N2 - The advent of next-generation sequencing has accelerated the implementation of genomic profiling in the care and management of patients with cancer. Initial efforts have focused on target identification in patients with advanced cancer. Prognostication, resistance detection, disease monitoring, and early detection efforts are also underway. This review highlights some of the challenges in this evolving space. This includes choosing between gene-panel and comprehensive approaches, DNA and transcriptome data integration, reduction of false-positive variants, addressing tumor heterogeneity, establishment of workflows to address unsolicited findings, and data sharing and privacy concerns.

AB - The advent of next-generation sequencing has accelerated the implementation of genomic profiling in the care and management of patients with cancer. Initial efforts have focused on target identification in patients with advanced cancer. Prognostication, resistance detection, disease monitoring, and early detection efforts are also underway. This review highlights some of the challenges in this evolving space. This includes choosing between gene-panel and comprehensive approaches, DNA and transcriptome data integration, reduction of false-positive variants, addressing tumor heterogeneity, establishment of workflows to address unsolicited findings, and data sharing and privacy concerns.

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Twenty-First Century Precision Medicine in Oncology: Genomic Profiling in Patients With Cancer

Abstract

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