Tumor markers in colorectal cancer

Predictors of risk

D. C. Rice, Heidi Nelson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Despite many advances, colorectal carcinoma remains a significant cause for death in the United States, in part because of delayed diagnosis and in part because of disease recurrence. Tumor markers offer potential to improve cancer therapy in a number of ways including: early detection of primary tumors; prediction of tumor behavior and response to treatment; monitoring responses to treatment; early detection of recurrences; and, more recently, diagnosis of genetic predisposition. In broad terms, there are three main categories of tumor markers: (1) tumor associated antigens, such as carcinoembryonic antigen and carbohydrate antigen 19-9; (2) markers of cellular proliferation, such as DNA ploidy and proliferative index; and (3) genetic markers, such as alterations in oncogenes and tumor-suppressor genes. This article discusses each category of tumor marker, with emphasis given to their roles in disease prognosis and monitoring response to treatment.

Original languageEnglish (US)
Pages (from-to)16-30
Number of pages15
JournalSeminars in Colon and Rectal Surgery
Volume7
Issue number1
StatePublished - 1996

Fingerprint

Tumor Biomarkers
Colorectal Neoplasms
Recurrence
Neoplasms
Ploidies
Delayed Diagnosis
Carcinoembryonic Antigen
Neoplasm Antigens
Therapeutics
Genetic Predisposition to Disease
Tumor Suppressor Genes
Genetic Markers
Oncogenes
Cause of Death
Carbohydrates
Cell Proliferation
Antigens
DNA

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery

Cite this

Tumor markers in colorectal cancer : Predictors of risk. / Rice, D. C.; Nelson, Heidi.

In: Seminars in Colon and Rectal Surgery, Vol. 7, No. 1, 1996, p. 16-30.

Research output: Contribution to journalArticle

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