Tumefactive cerebral amyloid angiopathy mimicking CNS neoplasm

Amy L. Kotsenas; Jonathan M. Morris; John T. Wald; Joseph E. Parisi; Norbert G. Campeau

doi:10.2214/AJR.12.8500

Tumefactive cerebral amyloid angiopathy mimicking CNS neoplasm

Amy L. Kotsenas, Jonathan M. Morris, John T. Wald, Joseph E. Parisi, Norbert G. Campeau

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

OBJECTIVE. The tumefactive variant of cerebral amyloid angiopathy (CAA) is rare. In this article we describe imaging findings associated with this entity and evaluate the role of susceptibility MRI sequences in its diagnosis. CONCLUSION. Our findings suggest that in elderly patients, susceptibility sequences should be part of prebiopsy MRI for tumefactive lesions. Identification of characteristic diffuse microhemorrhages should prompt inclusion of CAA in the differential diagnosis, targeted biopsy of the cortex and leptomeninges, and pathologic staining for CAA.

Original language	English (US)
Pages (from-to)	50-56
Number of pages	7
Journal	American Journal of Roentgenology
Volume	200
Issue number	1
DOIs	https://doi.org/10.2214/AJR.12.8500
State	Published - Jan 1 2013

Keywords

CNS
Cerebral amyloid angiopathy
Microhemorrhage
Neoplasm
Superficial hemosiderosis
Susceptibility MRI sequences

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.2214/AJR.12.8500

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title = "Tumefactive cerebral amyloid angiopathy mimicking CNS neoplasm",

abstract = "OBJECTIVE. The tumefactive variant of cerebral amyloid angiopathy (CAA) is rare. In this article we describe imaging findings associated with this entity and evaluate the role of susceptibility MRI sequences in its diagnosis. CONCLUSION. Our findings suggest that in elderly patients, susceptibility sequences should be part of prebiopsy MRI for tumefactive lesions. Identification of characteristic diffuse microhemorrhages should prompt inclusion of CAA in the differential diagnosis, targeted biopsy of the cortex and leptomeninges, and pathologic staining for CAA.",

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AU - Kotsenas, Amy L.

AU - Morris, Jonathan M.

AU - Wald, John T.

AU - Parisi, Joseph E.

AU - Campeau, Norbert G.

PY - 2013/1/1

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N2 - OBJECTIVE. The tumefactive variant of cerebral amyloid angiopathy (CAA) is rare. In this article we describe imaging findings associated with this entity and evaluate the role of susceptibility MRI sequences in its diagnosis. CONCLUSION. Our findings suggest that in elderly patients, susceptibility sequences should be part of prebiopsy MRI for tumefactive lesions. Identification of characteristic diffuse microhemorrhages should prompt inclusion of CAA in the differential diagnosis, targeted biopsy of the cortex and leptomeninges, and pathologic staining for CAA.

AB - OBJECTIVE. The tumefactive variant of cerebral amyloid angiopathy (CAA) is rare. In this article we describe imaging findings associated with this entity and evaluate the role of susceptibility MRI sequences in its diagnosis. CONCLUSION. Our findings suggest that in elderly patients, susceptibility sequences should be part of prebiopsy MRI for tumefactive lesions. Identification of characteristic diffuse microhemorrhages should prompt inclusion of CAA in the differential diagnosis, targeted biopsy of the cortex and leptomeninges, and pathologic staining for CAA.

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KW - Cerebral amyloid angiopathy

KW - Microhemorrhage

KW - Neoplasm

KW - Superficial hemosiderosis

KW - Susceptibility MRI sequences

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