Troponin elevations after electroconvulsive therapy

The need for caution

Matthew W. Martinez, Keith G. Rasmussen, Paul Mueller, Allan S Jaffe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Electroconvulsive therapy is used to treat patients with severe or resistant depression. Troponin elevations are associated with an adverse prognosis, and it is well known that central nervous system insults can cause biochemical evidence of cardiac injury. No study previously has studied this with electroconvulsive therapy. Methods: Patients scheduled for electroconvulsive therapy were enrolled. Clinical information, an electrocardiogram, and a baseline sample for cardiac troponin I and T (cTnI and cTnT) were obtained. Electroconvulsive therapy was done with standard techniques. Subsequently, electrocardiograms and additional samples were obtained. cTnT was measured with the Roche assay and cTnI with the Dade Stratus equipment. Values above the 99th percentile were considered abnormal. Results: Seventy patients completed the study. Four patients had elevated levels of cTn before treatment. In 3 patients, the elevations persisted. Four additional patients developed elevated cTn levels during electroconvulsive therapy. Two of the patients with cTn elevations died. No other events occurred during follow-up. Conclusions: Elevations of cTn occurred in 11.5% of patients treated with electroconvulsive therapy. Some of the elevations preceded therapy and some occurred during treatment. Given the adverse prognostic importance of cTn elevations in general, in addition to additional studies, an increased degree of medical scrutiny may be appropriate for this group of patients and for those receiving electroconvulsive therapy.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalAmerican Journal of Medicine
Volume124
Issue number3
DOIs
StatePublished - Mar 2011

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Electroconvulsive Therapy
Troponin
Electrocardiography
Troponin T
Troponin I
Therapeutics
Central Nervous System
Depression
Equipment and Supplies
Wounds and Injuries

Keywords

  • Electroconvulsive therapy
  • Troponin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Troponin elevations after electroconvulsive therapy : The need for caution. / Martinez, Matthew W.; Rasmussen, Keith G.; Mueller, Paul; Jaffe, Allan S.

In: American Journal of Medicine, Vol. 124, No. 3, 03.2011, p. 229-234.

Research output: Contribution to journalArticle

Martinez, Matthew W. ; Rasmussen, Keith G. ; Mueller, Paul ; Jaffe, Allan S. / Troponin elevations after electroconvulsive therapy : The need for caution. In: American Journal of Medicine. 2011 ; Vol. 124, No. 3. pp. 229-234.
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