Trisomy 5 in Ph+ chronic myeloid leukemia in association with megakaryocytosis

Stephen M. Ansell, Bernardo L. Rapoport, Maria A. Coccia-Portugal, Kenneth Stevens, Catharina J. Bester, Geoffrey Falkson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A patient with a megakaryocytosis associated with a Philadelphia chromosome-positive chronic myeloid leukemia (CML) was found to have a trisomy of chromosome five. To our knowledge, this is the first case of trisomy 5 associated with a Ph+ CML, particularly one with a megakaryocytosis. The trisomy 5 may be associated with the resistance to cytostatic drugs found in this patient.

Original languageEnglish (US)
Pages (from-to)273-275
Number of pages3
JournalCancer Genetics and Cytogenetics
Volume51
Issue number2
DOIs
StatePublished - Feb 1991

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Ansell, S. M., Rapoport, B. L., Coccia-Portugal, M. A., Stevens, K., Bester, C. J., & Falkson, G. (1991). Trisomy 5 in Ph+ chronic myeloid leukemia in association with megakaryocytosis. Cancer Genetics and Cytogenetics, 51(2), 273-275. https://doi.org/10.1016/0165-4608(91)90141-G