TY - JOUR
T1 - Trisomy 5 in Ph+ chronic myeloid leukemia in association with megakaryocytosis
AU - Ansell, Stephen M.
AU - Rapoport, Bernardo L.
AU - Coccia-Portugal, Maria A.
AU - Stevens, Kenneth
AU - Bester, Catharina J.
AU - Falkson, Geoffrey
PY - 1991/2
Y1 - 1991/2
N2 - A patient with a megakaryocytosis associated with a Philadelphia chromosome-positive chronic myeloid leukemia (CML) was found to have a trisomy of chromosome five. To our knowledge, this is the first case of trisomy 5 associated with a Ph+ CML, particularly one with a megakaryocytosis. The trisomy 5 may be associated with the resistance to cytostatic drugs found in this patient.
AB - A patient with a megakaryocytosis associated with a Philadelphia chromosome-positive chronic myeloid leukemia (CML) was found to have a trisomy of chromosome five. To our knowledge, this is the first case of trisomy 5 associated with a Ph+ CML, particularly one with a megakaryocytosis. The trisomy 5 may be associated with the resistance to cytostatic drugs found in this patient.
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U2 - 10.1016/0165-4608(91)90141-G
DO - 10.1016/0165-4608(91)90141-G
M3 - Article
C2 - 1993312
AN - SCOPUS:0026087419
SN - 0165-4608
VL - 51
SP - 273
EP - 275
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -