TY - JOUR
T1 - Trisomies in multiple myeloma
T2 - Impact on survival in patients with high-risk cytogenetics
AU - Kumar, Shaji
AU - Fonseca, Rafael
AU - Ketterling, Rhett P.
AU - Dispenzieri, Angela
AU - Lacy, Martha Q.
AU - Gertz, Morie A.
AU - Hayman, Suzanne R.
AU - Buadi, Francis K.
AU - Dingli, David
AU - Knudson, Ryan A.
AU - Greenberg, Alexandra
AU - Russell, Stephen J.
AU - Zeldenrust, Steven R.
AU - Lust, John A.
AU - Kyle, Robert A.
AU - Bergsagel, Leif
AU - Rajkumar, S. Vincent
PY - 2012/3/1
Y1 - 2012/3/1
N2 - Routine incorporation of FISH into multiple myeloma (MM) diagnostic testing has led to a better appreciation of the heterogeneity of genetic abnormalities associated with this disease. We studied a group of 484 patients with newly diagnosed symptomatic MM to better understand the prevalence of the various abnormalities and the prognostic significance of the overlapping abnormalities. A translocation involving the IgH locus and 1 of the 5 recurrent partner chromosomes was seen in 161 (33%) patients, and 275 (57%) had trisomy of at least 1 odd-numbered chromosome. High-risk FISH, defined as the presence of t(4;14), t(14;16), t(14;20), or loss of P53, was seen in 115 (24%) patients; the median overall survival for this group was 3.9 years, compared with "not reached" for standard-risk patients (P < .001). Among the patients with highrisk FISH, 49 patients who also had at least 1 trisomy had a median overall survival that was not reached, compared with 3 years for high-risk patients without a concurrent trisomy (P = .01). Based on the current findings, we conclude that the presence of trisomies in patients with t(4;14), t(14;16), t(14;20), or p53 deletion abnormalities inMMameliorates the usual adverse impact associated with these prognostic markers.
AB - Routine incorporation of FISH into multiple myeloma (MM) diagnostic testing has led to a better appreciation of the heterogeneity of genetic abnormalities associated with this disease. We studied a group of 484 patients with newly diagnosed symptomatic MM to better understand the prevalence of the various abnormalities and the prognostic significance of the overlapping abnormalities. A translocation involving the IgH locus and 1 of the 5 recurrent partner chromosomes was seen in 161 (33%) patients, and 275 (57%) had trisomy of at least 1 odd-numbered chromosome. High-risk FISH, defined as the presence of t(4;14), t(14;16), t(14;20), or loss of P53, was seen in 115 (24%) patients; the median overall survival for this group was 3.9 years, compared with "not reached" for standard-risk patients (P < .001). Among the patients with highrisk FISH, 49 patients who also had at least 1 trisomy had a median overall survival that was not reached, compared with 3 years for high-risk patients without a concurrent trisomy (P = .01). Based on the current findings, we conclude that the presence of trisomies in patients with t(4;14), t(14;16), t(14;20), or p53 deletion abnormalities inMMameliorates the usual adverse impact associated with these prognostic markers.
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U2 - 10.1182/blood-2011-11-390658
DO - 10.1182/blood-2011-11-390658
M3 - Article
C2 - 22234687
AN - SCOPUS:84863290659
SN - 0006-4971
VL - 119
SP - 2100
EP - 2105
JO - Blood
JF - Blood
IS - 9
ER -