TY - JOUR
T1 - Trends in the incidence of polycythemia vera among olmsted county, Minnesota residents, 1935–1989
AU - Anía, Basilio J.
AU - Suman, Vera J.
AU - Sobell, Janet L.
AU - Codd, Mary B.
AU - Silverstein, Murray N.
AU - Melton, L. Joseph
PY - 1994/10
Y1 - 1994/10
N2 - To investigate the suggestion that the incidence of polycythemia vera has increased in recent decades, we ascertained secular trends in the incidence of polycythemia vera in Olmsted County, Minnesota, over the 55‐year period, 1935–1989. The inpatient and outpatient medical records of all potential cases of polycythemia vera in Olmsted County residents were reviewed and the diagnostic criteria of the Polycythemia Vera Study Group were applied. We found no indication of an increase in the age‐ and sex‐adjusted incidence of polycythemia vera, which averaged 1.9 per 100,000 person‐years (95% C.I., 1.4–2.5) over the study period. Incidence rates increased with age, and age‐adjusted incidence rates were greater for men (2.8 per 100,000 person‐years; 95% C.I., 1.8–3.9) than for women (1.3 per 100,000 person‐years; 95% C.I., 0.7–1.9), with the highest incidence rate (23.5 per 100,000 person‐years) among men aged 70–79 years. Survival was reduced in this inception cohort of 50 cases, compared to that expected for individuals of like age and sex (P < 0.0001); median survival following diagnosis was 7.2 years. © 1994 Wiley‐Liss, Inc.
AB - To investigate the suggestion that the incidence of polycythemia vera has increased in recent decades, we ascertained secular trends in the incidence of polycythemia vera in Olmsted County, Minnesota, over the 55‐year period, 1935–1989. The inpatient and outpatient medical records of all potential cases of polycythemia vera in Olmsted County residents were reviewed and the diagnostic criteria of the Polycythemia Vera Study Group were applied. We found no indication of an increase in the age‐ and sex‐adjusted incidence of polycythemia vera, which averaged 1.9 per 100,000 person‐years (95% C.I., 1.4–2.5) over the study period. Incidence rates increased with age, and age‐adjusted incidence rates were greater for men (2.8 per 100,000 person‐years; 95% C.I., 1.8–3.9) than for women (1.3 per 100,000 person‐years; 95% C.I., 0.7–1.9), with the highest incidence rate (23.5 per 100,000 person‐years) among men aged 70–79 years. Survival was reduced in this inception cohort of 50 cases, compared to that expected for individuals of like age and sex (P < 0.0001); median survival following diagnosis was 7.2 years. © 1994 Wiley‐Liss, Inc.
KW - incidence
KW - polycythemia vera
KW - population‐based studies
KW - secular trend
UR - http://www.scopus.com/inward/record.url?scp=0027978142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027978142&partnerID=8YFLogxK
U2 - 10.1002/ajh.2830470205
DO - 10.1002/ajh.2830470205
M3 - Article
C2 - 8092146
AN - SCOPUS:0027978142
SN - 0361-8609
VL - 47
SP - 89
EP - 93
JO - American journal of hematology
JF - American journal of hematology
IS - 2
ER -