TY - JOUR
T1 - Trends in right and left-sided colon cancer
AU - Beart, Robert W.
AU - Melton, L. Joseph
AU - Maruta, Morito
AU - Dockerty, Malcolm B.
AU - Frydenberg, Harry B.
AU - O'Fallon, W. Michael
PY - 1983/6
Y1 - 1983/6
N2 - The increasing ratio of proximal to distal colorectal carcinomas was confirmed in this population-based study of 668 new cases diagnosed among Rochester, Minnesota residents between 1940 and 1979. The change was due to a rise in the incidence of proximal lesions (from 15.1 per 100,000 person-years in 1940-59 to 17.3 per 100,000 in 1960-79) and a simultaneous fall in the incidence of distal lesions (from 35.5 to 28.2 per 100,000 person-years). Changes in definitions or referral patterns played no role in these observations, although improved diagnostic capabilities may have had an impact on the incidence of proximal lesions. These discrepant changes in incidence strongly suggest that proximal and distal colonic cancers are different diseases or have a different pathogenesis. The changing incidence rates were not associated with consistent differences in clinical characteristics at the time of initial diagnosis.
AB - The increasing ratio of proximal to distal colorectal carcinomas was confirmed in this population-based study of 668 new cases diagnosed among Rochester, Minnesota residents between 1940 and 1979. The change was due to a rise in the incidence of proximal lesions (from 15.1 per 100,000 person-years in 1940-59 to 17.3 per 100,000 in 1960-79) and a simultaneous fall in the incidence of distal lesions (from 35.5 to 28.2 per 100,000 person-years). Changes in definitions or referral patterns played no role in these observations, although improved diagnostic capabilities may have had an impact on the incidence of proximal lesions. These discrepant changes in incidence strongly suggest that proximal and distal colonic cancers are different diseases or have a different pathogenesis. The changing incidence rates were not associated with consistent differences in clinical characteristics at the time of initial diagnosis.
KW - Carcinoma, colorectal
KW - Epidemiology
KW - Population-based study
UR - http://www.scopus.com/inward/record.url?scp=0020628011&partnerID=8YFLogxK
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U2 - 10.1007/BF02553382
DO - 10.1007/BF02553382
M3 - Article
C2 - 6851801
AN - SCOPUS:0020628011
SN - 0012-3706
VL - 26
SP - 393
EP - 398
JO - Diseases of the Colon & Rectum
JF - Diseases of the Colon & Rectum
IS - 6
ER -