Trends in Management of Intracranial Meningiomas

Analysis of 49,921 Cases from Modern Cohort

Vijay Agarwal, Brandon A. McCutcheon, Joshua D. Hughes, Matthew L. Carlson, Amy E. Glasgow, Elizabeth B Habermann, Quoc Bao Nguyen, Michael J. Link, Jamie Van Gompel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective We sought to characterize patterns and treatment for intracranial meningiomas in the Surveillance, Epidemiology, and End Results set of cancer registries. Methods SEER data was queried from 2004–2012 for cases of intracranial meningioma using appropriate topography and histology codes. Results A total of 49,921 patients with intracranial meningioma were identified. The vast majority of cases were associated with a benign histology (n = 47,047, 94.2%). There were 21,145 patients (42.4%) who underwent surgical management, 2783 who received radiation alone (5.6%), and 25,993 who underwent surveillance only (52.1%). Surgical management decreased in frequency from 48.8% of all cases in 2004 to 38.3% of cases in 2012 (P < 0.001). Radiation alone remained stable over time with a range of 4.8%−6.3% of cases. Observation increased from 45.0% of cases in 2004 to 56.7% of cases in 2012 (P < 0.001). On unadjusted analysis, surgical management was associated with younger age and larger tumor size. The incidence of tumors <2 cm in size increased significantly over the study period from 29.7% in 2004 to 41.7% in 2012 (P < 0.001). After adjusting for tumor size, multivariable analysis demonstrated that the odds of observation as a primary management strategy were greater in 2012 relative to 2004 (odds ratio 1.33, 95% confidence interval 1.21–1.45). Conclusion The incidence of intracranial meningiomas increased, while tumor size at the time of diagnosis decreased. Moreover, the number undergoing no treatment increased as a treatment strategy and was more likely employed for older patients, those of African-American race, and those with smaller tumors.

Original languageEnglish (US)
Pages (from-to)145-151
Number of pages7
JournalWorld Neurosurgery
Volume106
DOIs
StatePublished - Oct 1 2017

Fingerprint

Meningioma
Neoplasms
Histology
Observation
Radiation
Incidence
African Americans
Registries
Epidemiology
Therapeutics
Odds Ratio
Confidence Intervals

Keywords

  • Intracranial
  • Meningioma
  • Tumor management

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Trends in Management of Intracranial Meningiomas : Analysis of 49,921 Cases from Modern Cohort. / Agarwal, Vijay; McCutcheon, Brandon A.; Hughes, Joshua D.; Carlson, Matthew L.; Glasgow, Amy E.; Habermann, Elizabeth B; Nguyen, Quoc Bao; Link, Michael J.; Van Gompel, Jamie.

In: World Neurosurgery, Vol. 106, 01.10.2017, p. 145-151.

Research output: Contribution to journalArticle

Agarwal, Vijay ; McCutcheon, Brandon A. ; Hughes, Joshua D. ; Carlson, Matthew L. ; Glasgow, Amy E. ; Habermann, Elizabeth B ; Nguyen, Quoc Bao ; Link, Michael J. ; Van Gompel, Jamie. / Trends in Management of Intracranial Meningiomas : Analysis of 49,921 Cases from Modern Cohort. In: World Neurosurgery. 2017 ; Vol. 106. pp. 145-151.
@article{e9372ad4ec494f60bb39e334f6d1d0d5,
title = "Trends in Management of Intracranial Meningiomas: Analysis of 49,921 Cases from Modern Cohort",
abstract = "Objective We sought to characterize patterns and treatment for intracranial meningiomas in the Surveillance, Epidemiology, and End Results set of cancer registries. Methods SEER data was queried from 2004–2012 for cases of intracranial meningioma using appropriate topography and histology codes. Results A total of 49,921 patients with intracranial meningioma were identified. The vast majority of cases were associated with a benign histology (n = 47,047, 94.2{\%}). There were 21,145 patients (42.4{\%}) who underwent surgical management, 2783 who received radiation alone (5.6{\%}), and 25,993 who underwent surveillance only (52.1{\%}). Surgical management decreased in frequency from 48.8{\%} of all cases in 2004 to 38.3{\%} of cases in 2012 (P < 0.001). Radiation alone remained stable over time with a range of 4.8{\%}−6.3{\%} of cases. Observation increased from 45.0{\%} of cases in 2004 to 56.7{\%} of cases in 2012 (P < 0.001). On unadjusted analysis, surgical management was associated with younger age and larger tumor size. The incidence of tumors <2 cm in size increased significantly over the study period from 29.7{\%} in 2004 to 41.7{\%} in 2012 (P < 0.001). After adjusting for tumor size, multivariable analysis demonstrated that the odds of observation as a primary management strategy were greater in 2012 relative to 2004 (odds ratio 1.33, 95{\%} confidence interval 1.21–1.45). Conclusion The incidence of intracranial meningiomas increased, while tumor size at the time of diagnosis decreased. Moreover, the number undergoing no treatment increased as a treatment strategy and was more likely employed for older patients, those of African-American race, and those with smaller tumors.",
keywords = "Intracranial, Meningioma, Tumor management",
author = "Vijay Agarwal and McCutcheon, {Brandon A.} and Hughes, {Joshua D.} and Carlson, {Matthew L.} and Glasgow, {Amy E.} and Habermann, {Elizabeth B} and Nguyen, {Quoc Bao} and Link, {Michael J.} and {Van Gompel}, Jamie",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.wneu.2017.06.127",
language = "English (US)",
volume = "106",
pages = "145--151",
journal = "World Neurosurgery",
issn = "1878-8750",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Trends in Management of Intracranial Meningiomas

T2 - Analysis of 49,921 Cases from Modern Cohort

AU - Agarwal, Vijay

AU - McCutcheon, Brandon A.

AU - Hughes, Joshua D.

AU - Carlson, Matthew L.

AU - Glasgow, Amy E.

AU - Habermann, Elizabeth B

AU - Nguyen, Quoc Bao

AU - Link, Michael J.

AU - Van Gompel, Jamie

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Objective We sought to characterize patterns and treatment for intracranial meningiomas in the Surveillance, Epidemiology, and End Results set of cancer registries. Methods SEER data was queried from 2004–2012 for cases of intracranial meningioma using appropriate topography and histology codes. Results A total of 49,921 patients with intracranial meningioma were identified. The vast majority of cases were associated with a benign histology (n = 47,047, 94.2%). There were 21,145 patients (42.4%) who underwent surgical management, 2783 who received radiation alone (5.6%), and 25,993 who underwent surveillance only (52.1%). Surgical management decreased in frequency from 48.8% of all cases in 2004 to 38.3% of cases in 2012 (P < 0.001). Radiation alone remained stable over time with a range of 4.8%−6.3% of cases. Observation increased from 45.0% of cases in 2004 to 56.7% of cases in 2012 (P < 0.001). On unadjusted analysis, surgical management was associated with younger age and larger tumor size. The incidence of tumors <2 cm in size increased significantly over the study period from 29.7% in 2004 to 41.7% in 2012 (P < 0.001). After adjusting for tumor size, multivariable analysis demonstrated that the odds of observation as a primary management strategy were greater in 2012 relative to 2004 (odds ratio 1.33, 95% confidence interval 1.21–1.45). Conclusion The incidence of intracranial meningiomas increased, while tumor size at the time of diagnosis decreased. Moreover, the number undergoing no treatment increased as a treatment strategy and was more likely employed for older patients, those of African-American race, and those with smaller tumors.

AB - Objective We sought to characterize patterns and treatment for intracranial meningiomas in the Surveillance, Epidemiology, and End Results set of cancer registries. Methods SEER data was queried from 2004–2012 for cases of intracranial meningioma using appropriate topography and histology codes. Results A total of 49,921 patients with intracranial meningioma were identified. The vast majority of cases were associated with a benign histology (n = 47,047, 94.2%). There were 21,145 patients (42.4%) who underwent surgical management, 2783 who received radiation alone (5.6%), and 25,993 who underwent surveillance only (52.1%). Surgical management decreased in frequency from 48.8% of all cases in 2004 to 38.3% of cases in 2012 (P < 0.001). Radiation alone remained stable over time with a range of 4.8%−6.3% of cases. Observation increased from 45.0% of cases in 2004 to 56.7% of cases in 2012 (P < 0.001). On unadjusted analysis, surgical management was associated with younger age and larger tumor size. The incidence of tumors <2 cm in size increased significantly over the study period from 29.7% in 2004 to 41.7% in 2012 (P < 0.001). After adjusting for tumor size, multivariable analysis demonstrated that the odds of observation as a primary management strategy were greater in 2012 relative to 2004 (odds ratio 1.33, 95% confidence interval 1.21–1.45). Conclusion The incidence of intracranial meningiomas increased, while tumor size at the time of diagnosis decreased. Moreover, the number undergoing no treatment increased as a treatment strategy and was more likely employed for older patients, those of African-American race, and those with smaller tumors.

KW - Intracranial

KW - Meningioma

KW - Tumor management

UR - http://www.scopus.com/inward/record.url?scp=85024474444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024474444&partnerID=8YFLogxK

U2 - 10.1016/j.wneu.2017.06.127

DO - 10.1016/j.wneu.2017.06.127

M3 - Article

VL - 106

SP - 145

EP - 151

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

ER -