Treatment prospects for autosomal-dominant polycystic kidney disease

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45 Scopus citations


Treatment prospects for autosomal-dominant polycystic kidney disease. An increased understanding of the molecular genetic and cellular pathophysiologic mechanisms responsible for the development of autosomal-dominant polycystic kidney disease (ADPKD), made possible by the advances in molecular biology and genetics of the last three decades, has laid the foundation for the development of effective therapies. As the concept that a polycystic kidney is a neoplasm in disguise is becoming increasingly accepted, the development of therapies for ADPKD may benefit greatly from the expanding body of information on cancer chemoprevention and chemosuppression. This review summarizes the observations that already have been made and discusses therapies for PKD that deserve investigation.

Original languageEnglish (US)
Pages (from-to)2005-2022
Number of pages18
JournalKidney international
Issue number6
StatePublished - 2001


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  • Tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Nephrology


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