Treatment outcomes of human bartonellosis: A systematic review and meta-analysis

Gabriela Prutsky, Juan Pablo Domecq, Laura Mori, Serge Bebko, Melissa Matzumura, Amar Sabouni, Anas Shahrour, Patricia J. Erwin, Thomas G. Boyce, Victor Manuel Montori, German Malaga, Mohammad H Murad

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Bartonella henselae, Bartonella quintana, and Bartonella bacilliformis are responsible for the majority of cases of bartonellosis in humans. These species have various unique epidemiologic characteristics, clinical manifestations, and treatment approaches. The objective of this study was to summarize the evidence on the treatment for the three most common species of Bartonella in humans. Methods: We searched electronic databases through August 2011 for randomized controlled trials and observational studies designed to evaluate the efficacy and safety of the regimens used to treat diseases produced by B. henselae, B. quintana, and B. bacilliformis. Study selection and appraisal were done in duplicate. Results: We found two randomized and seven non-randomized studies at high risk of bias. For cat scratch disease, antibiotics did not significantly affect the cure rate or time to achieve cure. In chronic bacteremia, gentamicin and doxycycline significantly increased the resolution rate. The recommended treatment was not better than other regimens for infectious endocarditis and bacillary angiomatosis. Conclusions: Current clinical practice for the treatment of bartonellosis relies mostly on expert opinion and antimicrobial susceptibility data. Randomized controlled trials are needed in the field to compare different treatment options.

Original languageEnglish (US)
JournalInternational Journal of Infectious Diseases
Volume17
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Bartonella bacilliformis
Bartonella quintana
Bartonella Infections
Bartonella henselae
Meta-Analysis
Bacillary Angiomatosis
Randomized Controlled Trials
Bartonella
Cat-Scratch Disease
Doxycycline
Expert Testimony
Bacteremia
Endocarditis
Gentamicins
Observational Studies
Databases
Anti-Bacterial Agents
Safety

Keywords

  • Antibiotic treatment
  • Bacillary angiomatosis
  • Bartonella bacilliformis
  • Bartonella henselae
  • Bartonella quintana
  • Bartonellosis
  • Cat scratch disease

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Treatment outcomes of human bartonellosis : A systematic review and meta-analysis. / Prutsky, Gabriela; Domecq, Juan Pablo; Mori, Laura; Bebko, Serge; Matzumura, Melissa; Sabouni, Amar; Shahrour, Anas; Erwin, Patricia J.; Boyce, Thomas G.; Montori, Victor Manuel; Malaga, German; Murad, Mohammad H.

In: International Journal of Infectious Diseases, Vol. 17, No. 10, 10.2013.

Research output: Contribution to journalArticle

Prutsky, G, Domecq, JP, Mori, L, Bebko, S, Matzumura, M, Sabouni, A, Shahrour, A, Erwin, PJ, Boyce, TG, Montori, VM, Malaga, G & Murad, MH 2013, 'Treatment outcomes of human bartonellosis: A systematic review and meta-analysis', International Journal of Infectious Diseases, vol. 17, no. 10. https://doi.org/10.1016/j.ijid.2013.02.016
Prutsky, Gabriela ; Domecq, Juan Pablo ; Mori, Laura ; Bebko, Serge ; Matzumura, Melissa ; Sabouni, Amar ; Shahrour, Anas ; Erwin, Patricia J. ; Boyce, Thomas G. ; Montori, Victor Manuel ; Malaga, German ; Murad, Mohammad H. / Treatment outcomes of human bartonellosis : A systematic review and meta-analysis. In: International Journal of Infectious Diseases. 2013 ; Vol. 17, No. 10.
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