TY - JOUR
T1 - Treatment of older patients with chronic lymphocytic leukemia
T2 - key questions and current answers
AU - Shanafelt, Tait
PY - 2013
Y1 - 2013
N2 - Despite the advanced age at onset, chronic lymphocytic leukemia (CLL) shortens the life expectancy of the majority of newly diagnosed patients. The management of elderly patients with CLL is more complex than that of younger patients due to the greater frequency of comorbidities and functional impairment as well as reduced organ function. Many of the recent advances in the care of CLL patients (prognostication, more intense combination therapy regimens) are of unclear relevance for elderly patients. This review addresses 5 key questions in the management of elderly patients with CLL: (1) why is classifying the "fitness" of CLL patients necessary; (2) what criteria should be used to classify patient fitness; (3) when should elderly patients be treated; (4) how should therapy be selected for elderly patients; and (5) which therapy is best (for this patient)?
AB - Despite the advanced age at onset, chronic lymphocytic leukemia (CLL) shortens the life expectancy of the majority of newly diagnosed patients. The management of elderly patients with CLL is more complex than that of younger patients due to the greater frequency of comorbidities and functional impairment as well as reduced organ function. Many of the recent advances in the care of CLL patients (prognostication, more intense combination therapy regimens) are of unclear relevance for elderly patients. This review addresses 5 key questions in the management of elderly patients with CLL: (1) why is classifying the "fitness" of CLL patients necessary; (2) what criteria should be used to classify patient fitness; (3) when should elderly patients be treated; (4) how should therapy be selected for elderly patients; and (5) which therapy is best (for this patient)?
UR - http://www.scopus.com/inward/record.url?scp=84896323847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896323847&partnerID=8YFLogxK
U2 - 10.1182/asheducation-2013.1.158
DO - 10.1182/asheducation-2013.1.158
M3 - Review article
C2 - 24319177
AN - SCOPUS:84896323847
SN - 1520-4391
VL - 2013
SP - 158
EP - 167
JO - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
JF - Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program
ER -