Treatment of multiple myeloma

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

The treatment of multiple myeloma has changed dramatically in the past decade. The increase in the number of active agents has generated numerous possible drug combinations that can be used in the first-line and relapsed settings. As a result, there is considerable confusion about the choice of regimens for initial therapy, role of transplantation in the era of new drugs, end points for therapy, and the role of maintenance therapy. A hotly debated area is whether treatment approaches should achieve cure or disease control, which impacts greatly on the treatment strategy employed. This article provides an update on the treatment of multiple myeloma, with a focus on recent advances, newly diagnosed disease, role of transplantation and maintenance therapy. A synthesized approach to the treatment of myeloma is presented, along with a discussion of key paradigms that need to be challenged.

Original languageEnglish (US)
Pages (from-to)479-491
Number of pages13
JournalNature Reviews Clinical Oncology
Volume8
Issue number8
DOIs
StatePublished - Aug 2011

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Multiple Myeloma
Transplantation
Drug Combinations
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Oncology

Cite this

Treatment of multiple myeloma. / Rajkumar, S Vincent.

In: Nature Reviews Clinical Oncology, Vol. 8, No. 8, 08.2011, p. 479-491.

Research output: Contribution to journalArticle

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