Treatment of arrhythmias by external charged particle beams: A Langendorff feasibility study

Matthias Prall, H. Immo Lehmann, Hannah Prokesch, Daniel Richter, Christian Graeff, Robert Kaderka, Karin Sonnenberg, Henrik Hauswald, Alexander Weymann, Julia Bauer, Anna Constantinescu, Thomas Haberer, Jürgen Debus, Gábor Szabó, Sevil Korkmaz, Marco Durante, Douglas L Packer, Christoph Bert

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hadron therapy has already proven to be successful in cancer therapy, and might be a noninvasive alternative for the ablation of cardiac arrhythmias in humans. We present a pilot experiment investigating acute effects of a 12C irradiation on the AV nodes of porcine hearts in a Langendorff setup. This setup was adapted to the requirements of charged particle therapy. Treatment plans were computed on calibrated CTs of the hearts. Irradiation was applied in units of 5 and 10 Gy over a period of about 3 h until a total dose of up to 160 Gy was reached. Repeated application of the same irradiation field helped to mitigate motion artifacts in the resulting dose distribution. After irradiation, PET scans were performed to verify accurate dose application. Acute AV blocks were identified. No other acute effects were observed. Hearts were kept in sinus rhythm for up to 6 h in the Langendorff setup. We demonstrated that 12C ions can be used to select a small target in the heart and, thereby, influence the electrical conduction system. Second, our pilot study seems to suggest that no adverse effects have to be expected immediately during heavy ion irradiation in performing subsequent experiments with doses of 30-60 Gy and intact pigs.

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalBiomedizinische Technik
Volume60
Issue number2
DOIs
StatePublished - Apr 1 2015

Fingerprint

Particle beams
Charged particles
Irradiation
Dosimetry
Ion bombardment
Ablation
Heavy ions
Experiments
Ions

Keywords

  • ablation
  • cardiac arrhythmia
  • hadron therapy
  • moving organs
  • noninvasive interventions
  • treatment planning

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Prall, M., Lehmann, H. I., Prokesch, H., Richter, D., Graeff, C., Kaderka, R., ... Bert, C. (2015). Treatment of arrhythmias by external charged particle beams: A Langendorff feasibility study. Biomedizinische Technik, 60(2), 147-156. https://doi.org/10.1515/bmt-2014-0101

Treatment of arrhythmias by external charged particle beams : A Langendorff feasibility study. / Prall, Matthias; Lehmann, H. Immo; Prokesch, Hannah; Richter, Daniel; Graeff, Christian; Kaderka, Robert; Sonnenberg, Karin; Hauswald, Henrik; Weymann, Alexander; Bauer, Julia; Constantinescu, Anna; Haberer, Thomas; Debus, Jürgen; Szabó, Gábor; Korkmaz, Sevil; Durante, Marco; Packer, Douglas L; Bert, Christoph.

In: Biomedizinische Technik, Vol. 60, No. 2, 01.04.2015, p. 147-156.

Research output: Contribution to journalArticle

Prall, M, Lehmann, HI, Prokesch, H, Richter, D, Graeff, C, Kaderka, R, Sonnenberg, K, Hauswald, H, Weymann, A, Bauer, J, Constantinescu, A, Haberer, T, Debus, J, Szabó, G, Korkmaz, S, Durante, M, Packer, DL & Bert, C 2015, 'Treatment of arrhythmias by external charged particle beams: A Langendorff feasibility study', Biomedizinische Technik, vol. 60, no. 2, pp. 147-156. https://doi.org/10.1515/bmt-2014-0101
Prall, Matthias ; Lehmann, H. Immo ; Prokesch, Hannah ; Richter, Daniel ; Graeff, Christian ; Kaderka, Robert ; Sonnenberg, Karin ; Hauswald, Henrik ; Weymann, Alexander ; Bauer, Julia ; Constantinescu, Anna ; Haberer, Thomas ; Debus, Jürgen ; Szabó, Gábor ; Korkmaz, Sevil ; Durante, Marco ; Packer, Douglas L ; Bert, Christoph. / Treatment of arrhythmias by external charged particle beams : A Langendorff feasibility study. In: Biomedizinische Technik. 2015 ; Vol. 60, No. 2. pp. 147-156.
@article{a5094daf78ba4affa8b2d9fca8676c8d,
title = "Treatment of arrhythmias by external charged particle beams: A Langendorff feasibility study",
abstract = "Hadron therapy has already proven to be successful in cancer therapy, and might be a noninvasive alternative for the ablation of cardiac arrhythmias in humans. We present a pilot experiment investigating acute effects of a 12C irradiation on the AV nodes of porcine hearts in a Langendorff setup. This setup was adapted to the requirements of charged particle therapy. Treatment plans were computed on calibrated CTs of the hearts. Irradiation was applied in units of 5 and 10 Gy over a period of about 3 h until a total dose of up to 160 Gy was reached. Repeated application of the same irradiation field helped to mitigate motion artifacts in the resulting dose distribution. After irradiation, PET scans were performed to verify accurate dose application. Acute AV blocks were identified. No other acute effects were observed. Hearts were kept in sinus rhythm for up to 6 h in the Langendorff setup. We demonstrated that 12C ions can be used to select a small target in the heart and, thereby, influence the electrical conduction system. Second, our pilot study seems to suggest that no adverse effects have to be expected immediately during heavy ion irradiation in performing subsequent experiments with doses of 30-60 Gy and intact pigs.",
keywords = "ablation, cardiac arrhythmia, hadron therapy, moving organs, noninvasive interventions, treatment planning",
author = "Matthias Prall and Lehmann, {H. Immo} and Hannah Prokesch and Daniel Richter and Christian Graeff and Robert Kaderka and Karin Sonnenberg and Henrik Hauswald and Alexander Weymann and Julia Bauer and Anna Constantinescu and Thomas Haberer and J{\"u}rgen Debus and G{\'a}bor Szab{\'o} and Sevil Korkmaz and Marco Durante and Packer, {Douglas L} and Christoph Bert",
year = "2015",
month = "4",
day = "1",
doi = "10.1515/bmt-2014-0101",
language = "English (US)",
volume = "60",
pages = "147--156",
journal = "Biomedizinische Technik. Biomedical engineering",
issn = "0013-5585",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "2",

}

TY - JOUR

T1 - Treatment of arrhythmias by external charged particle beams

T2 - A Langendorff feasibility study

AU - Prall, Matthias

AU - Lehmann, H. Immo

AU - Prokesch, Hannah

AU - Richter, Daniel

AU - Graeff, Christian

AU - Kaderka, Robert

AU - Sonnenberg, Karin

AU - Hauswald, Henrik

AU - Weymann, Alexander

AU - Bauer, Julia

AU - Constantinescu, Anna

AU - Haberer, Thomas

AU - Debus, Jürgen

AU - Szabó, Gábor

AU - Korkmaz, Sevil

AU - Durante, Marco

AU - Packer, Douglas L

AU - Bert, Christoph

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Hadron therapy has already proven to be successful in cancer therapy, and might be a noninvasive alternative for the ablation of cardiac arrhythmias in humans. We present a pilot experiment investigating acute effects of a 12C irradiation on the AV nodes of porcine hearts in a Langendorff setup. This setup was adapted to the requirements of charged particle therapy. Treatment plans were computed on calibrated CTs of the hearts. Irradiation was applied in units of 5 and 10 Gy over a period of about 3 h until a total dose of up to 160 Gy was reached. Repeated application of the same irradiation field helped to mitigate motion artifacts in the resulting dose distribution. After irradiation, PET scans were performed to verify accurate dose application. Acute AV blocks were identified. No other acute effects were observed. Hearts were kept in sinus rhythm for up to 6 h in the Langendorff setup. We demonstrated that 12C ions can be used to select a small target in the heart and, thereby, influence the electrical conduction system. Second, our pilot study seems to suggest that no adverse effects have to be expected immediately during heavy ion irradiation in performing subsequent experiments with doses of 30-60 Gy and intact pigs.

AB - Hadron therapy has already proven to be successful in cancer therapy, and might be a noninvasive alternative for the ablation of cardiac arrhythmias in humans. We present a pilot experiment investigating acute effects of a 12C irradiation on the AV nodes of porcine hearts in a Langendorff setup. This setup was adapted to the requirements of charged particle therapy. Treatment plans were computed on calibrated CTs of the hearts. Irradiation was applied in units of 5 and 10 Gy over a period of about 3 h until a total dose of up to 160 Gy was reached. Repeated application of the same irradiation field helped to mitigate motion artifacts in the resulting dose distribution. After irradiation, PET scans were performed to verify accurate dose application. Acute AV blocks were identified. No other acute effects were observed. Hearts were kept in sinus rhythm for up to 6 h in the Langendorff setup. We demonstrated that 12C ions can be used to select a small target in the heart and, thereby, influence the electrical conduction system. Second, our pilot study seems to suggest that no adverse effects have to be expected immediately during heavy ion irradiation in performing subsequent experiments with doses of 30-60 Gy and intact pigs.

KW - ablation

KW - cardiac arrhythmia

KW - hadron therapy

KW - moving organs

KW - noninvasive interventions

KW - treatment planning

UR - http://www.scopus.com/inward/record.url?scp=84926677198&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926677198&partnerID=8YFLogxK

U2 - 10.1515/bmt-2014-0101

DO - 10.1515/bmt-2014-0101

M3 - Article

C2 - 25719279

AN - SCOPUS:84926677198

VL - 60

SP - 147

EP - 156

JO - Biomedizinische Technik. Biomedical engineering

JF - Biomedizinische Technik. Biomedical engineering

SN - 0013-5585

IS - 2

ER -