Treadmill exercise suppresses food-deprivation-induced increase of nitric oxide synthase expression in rat paraventricular nucleus

Sung Soo Kim; Hong Kim; Sam Jun Lee; Hyun Kyung Chang; Min Chul Shin; Mi Hyeon Jang; Mal Soon Shin; Chang Ju Kim

doi:10.1016/j.neulet.2003.09.012

Treadmill exercise suppresses food-deprivation-induced increase of nitric oxide synthase expression in rat paraventricular nucleus

Sung Soo Kim, Hong Kim, Sam Jun Lee, Hyun Kyung Chang, Min Chul Shin, Mi Hyeon Jang, Mal Soon Shin, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Exercise is known to potentially affect the eating patterns. In the present study, the effect of treadmill exercise on the expressions of nitric oxide synthase (NOS) and neuronal nitric oxide synthase (nNOS) in the paraventricular nucleus (PVN) of food-deprived rats was investigated using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and nNOS immunohistochemistry. The present results showed that food deprivation increased NOS and nNOS expressions in the PVN of the hypothalamus and treadmill exercise suppressed food deprivation-induced enhancing of NOS and nNOS expressions in the PVN. The most suppressive effect of treadmill exercise on the expressions of NOS and nNOS were observed in the heavy-intensity exercise group. Based on the present study, it is possible that treadmill exercise alleviates desire for food under food-deprivation conditions via modulation of NOS expression.

Original language	English (US)
Pages (from-to)	41-44
Number of pages	4
Journal	Neuroscience Letters
Volume	353
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2003.09.012
State	Published - Dec 15 2003

Keywords

Food deprivation
Nitric oxide synthase
Paraventricular nucleus
Treadmill exercise

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2003.09.012

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title = "Treadmill exercise suppresses food-deprivation-induced increase of nitric oxide synthase expression in rat paraventricular nucleus",

abstract = "Exercise is known to potentially affect the eating patterns. In the present study, the effect of treadmill exercise on the expressions of nitric oxide synthase (NOS) and neuronal nitric oxide synthase (nNOS) in the paraventricular nucleus (PVN) of food-deprived rats was investigated using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and nNOS immunohistochemistry. The present results showed that food deprivation increased NOS and nNOS expressions in the PVN of the hypothalamus and treadmill exercise suppressed food deprivation-induced enhancing of NOS and nNOS expressions in the PVN. The most suppressive effect of treadmill exercise on the expressions of NOS and nNOS were observed in the heavy-intensity exercise group. Based on the present study, it is possible that treadmill exercise alleviates desire for food under food-deprivation conditions via modulation of NOS expression.",

keywords = "Food deprivation, Nitric oxide synthase, Paraventricular nucleus, Treadmill exercise",

author = "Kim, {Sung Soo} and Hong Kim and Lee, {Sam Jun} and Chang, {Hyun Kyung} and Shin, {Min Chul} and Jang, {Mi Hyeon} and Shin, {Mal Soon} and Kim, {Chang Ju}",

note = "Funding Information: This work was supported by a Korea Research Foundation Grant (KRF-2002-041-G00085).",

year = "2003",

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doi = "10.1016/j.neulet.2003.09.012",

language = "English (US)",

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T1 - Treadmill exercise suppresses food-deprivation-induced increase of nitric oxide synthase expression in rat paraventricular nucleus

AU - Kim, Sung Soo

AU - Kim, Hong

AU - Lee, Sam Jun

AU - Chang, Hyun Kyung

AU - Shin, Min Chul

AU - Jang, Mi Hyeon

AU - Shin, Mal Soon

AU - Kim, Chang Ju

N1 - Funding Information: This work was supported by a Korea Research Foundation Grant (KRF-2002-041-G00085).

PY - 2003/12/15

Y1 - 2003/12/15

N2 - Exercise is known to potentially affect the eating patterns. In the present study, the effect of treadmill exercise on the expressions of nitric oxide synthase (NOS) and neuronal nitric oxide synthase (nNOS) in the paraventricular nucleus (PVN) of food-deprived rats was investigated using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and nNOS immunohistochemistry. The present results showed that food deprivation increased NOS and nNOS expressions in the PVN of the hypothalamus and treadmill exercise suppressed food deprivation-induced enhancing of NOS and nNOS expressions in the PVN. The most suppressive effect of treadmill exercise on the expressions of NOS and nNOS were observed in the heavy-intensity exercise group. Based on the present study, it is possible that treadmill exercise alleviates desire for food under food-deprivation conditions via modulation of NOS expression.

AB - Exercise is known to potentially affect the eating patterns. In the present study, the effect of treadmill exercise on the expressions of nitric oxide synthase (NOS) and neuronal nitric oxide synthase (nNOS) in the paraventricular nucleus (PVN) of food-deprived rats was investigated using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and nNOS immunohistochemistry. The present results showed that food deprivation increased NOS and nNOS expressions in the PVN of the hypothalamus and treadmill exercise suppressed food deprivation-induced enhancing of NOS and nNOS expressions in the PVN. The most suppressive effect of treadmill exercise on the expressions of NOS and nNOS were observed in the heavy-intensity exercise group. Based on the present study, it is possible that treadmill exercise alleviates desire for food under food-deprivation conditions via modulation of NOS expression.

KW - Food deprivation

KW - Nitric oxide synthase

KW - Paraventricular nucleus

KW - Treadmill exercise

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Treadmill exercise suppresses food-deprivation-induced increase of nitric oxide synthase expression in rat paraventricular nucleus

Abstract

Keywords

ASJC Scopus subject areas

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