Treadmill exercise suppresses food-deprivation-induced increase of nitric oxide synthase expression in rat paraventricular nucleus

Sung Soo Kim, Hong Kim, Sam Jun Lee, Hyun Kyung Chang, Min Chul Shin, Mi-Hyeon D Jang, Mal Soon Shin, Chang Ju Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Exercise is known to potentially affect the eating patterns. In the present study, the effect of treadmill exercise on the expressions of nitric oxide synthase (NOS) and neuronal nitric oxide synthase (nNOS) in the paraventricular nucleus (PVN) of food-deprived rats was investigated using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and nNOS immunohistochemistry. The present results showed that food deprivation increased NOS and nNOS expressions in the PVN of the hypothalamus and treadmill exercise suppressed food deprivation-induced enhancing of NOS and nNOS expressions in the PVN. The most suppressive effect of treadmill exercise on the expressions of NOS and nNOS were observed in the heavy-intensity exercise group. Based on the present study, it is possible that treadmill exercise alleviates desire for food under food-deprivation conditions via modulation of NOS expression.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Volume353
Issue number1
DOIs
StatePublished - Dec 15 2003
Externally publishedYes

Fingerprint

Food Deprivation
Nitric Oxide Synthase Type I
Paraventricular Hypothalamic Nucleus
Nitric Oxide Synthase
Food
NADP
Hypothalamus
Eating
Immunohistochemistry

Keywords

  • Food deprivation
  • Nitric oxide synthase
  • Paraventricular nucleus
  • Treadmill exercise

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Treadmill exercise suppresses food-deprivation-induced increase of nitric oxide synthase expression in rat paraventricular nucleus. / Kim, Sung Soo; Kim, Hong; Lee, Sam Jun; Chang, Hyun Kyung; Shin, Min Chul; Jang, Mi-Hyeon D; Shin, Mal Soon; Kim, Chang Ju.

In: Neuroscience Letters, Vol. 353, No. 1, 15.12.2003, p. 41-44.

Research output: Contribution to journalArticle

Kim, Sung Soo ; Kim, Hong ; Lee, Sam Jun ; Chang, Hyun Kyung ; Shin, Min Chul ; Jang, Mi-Hyeon D ; Shin, Mal Soon ; Kim, Chang Ju. / Treadmill exercise suppresses food-deprivation-induced increase of nitric oxide synthase expression in rat paraventricular nucleus. In: Neuroscience Letters. 2003 ; Vol. 353, No. 1. pp. 41-44.
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AU - Jang, Mi-Hyeon D

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