Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats

Mal Soon Shin; Hong Kim; Hyun Kyung Chang; Taeck Hyun Lee; Mi Hyeon Jang; Min Chul Shin; Baek Vin Lim; Hee Hyuk Lee; Young Pyo Kim; Jin Hwan Yoon; Il Gyu Jeong; Chang Ju Kim

doi:10.1016/S0304-3940(03)00537-8

Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats

Mal Soon Shin, Hong Kim, Hyun Kyung Chang, Taeck Hyun Lee, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Hee Hyuk Lee, Young Pyo Kim, Jin Hwan Yoon, Il Gyu Jeong, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Diabetes mellitus is a metabolic disorder with serious sequelae in humans. Hyperphagia is a characteristic symptom of diabetes and is a central nervous system-mediated disorder. Neuropeptide Y (NPY) is a 36-amino-acid peptide and is concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill exercise on the hypothalamic NPY expression in rats with streptozotocin (STZ)-induced diabetes was investigated via immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus and arcuate nucleus was observed in the STZ-induced diabetic rats. Treadmill exercise suppressed a diabetes-induced increase of NPY expression. The present results suggest the possibility that treadmill exercise inhibits diabetes-induced increment of the desire for food.

Original language	English (US)
Pages (from-to)	157-160
Number of pages	4
Journal	Neuroscience Letters
Volume	346
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(03)00537-8
State	Published - Aug 7 2003

Keywords

Arcuate nucleus
Diabetes
Neuropeptide Y
Paraventricular nucleus
Treadmill exercise

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(03)00537-8

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title = "Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats",

abstract = "Diabetes mellitus is a metabolic disorder with serious sequelae in humans. Hyperphagia is a characteristic symptom of diabetes and is a central nervous system-mediated disorder. Neuropeptide Y (NPY) is a 36-amino-acid peptide and is concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill exercise on the hypothalamic NPY expression in rats with streptozotocin (STZ)-induced diabetes was investigated via immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus and arcuate nucleus was observed in the STZ-induced diabetic rats. Treadmill exercise suppressed a diabetes-induced increase of NPY expression. The present results suggest the possibility that treadmill exercise inhibits diabetes-induced increment of the desire for food.",

keywords = "Arcuate nucleus, Diabetes, Neuropeptide Y, Paraventricular nucleus, Treadmill exercise",

author = "Shin, {Mal Soon} and Hong Kim and Chang, {Hyun Kyung} and Lee, {Taeck Hyun} and Jang, {Mi Hyeon} and Shin, {Min Chul} and Lim, {Baek Vin} and Lee, {Hee Hyuk} and Kim, {Young Pyo} and Yoon, {Jin Hwan} and Jeong, {Il Gyu} and Kim, {Chang Ju}",

note = "Funding Information: This work was supported by a Korea Research Foundation Grant (KRF-2002-037-G00022). ",

year = "2003",

month = aug,

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doi = "10.1016/S0304-3940(03)00537-8",

language = "English (US)",

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T1 - Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats

AU - Shin, Mal Soon

AU - Kim, Hong

AU - Chang, Hyun Kyung

AU - Lee, Taeck Hyun

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lim, Baek Vin

AU - Lee, Hee Hyuk

AU - Kim, Young Pyo

AU - Yoon, Jin Hwan

AU - Jeong, Il Gyu

AU - Kim, Chang Ju

N1 - Funding Information: This work was supported by a Korea Research Foundation Grant (KRF-2002-037-G00022).

PY - 2003/8/7

Y1 - 2003/8/7

N2 - Diabetes mellitus is a metabolic disorder with serious sequelae in humans. Hyperphagia is a characteristic symptom of diabetes and is a central nervous system-mediated disorder. Neuropeptide Y (NPY) is a 36-amino-acid peptide and is concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill exercise on the hypothalamic NPY expression in rats with streptozotocin (STZ)-induced diabetes was investigated via immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus and arcuate nucleus was observed in the STZ-induced diabetic rats. Treadmill exercise suppressed a diabetes-induced increase of NPY expression. The present results suggest the possibility that treadmill exercise inhibits diabetes-induced increment of the desire for food.

AB - Diabetes mellitus is a metabolic disorder with serious sequelae in humans. Hyperphagia is a characteristic symptom of diabetes and is a central nervous system-mediated disorder. Neuropeptide Y (NPY) is a 36-amino-acid peptide and is concentrated in the hypothalamus which is an appetite-regulating area. NPY is known to stimulate appetite and decrease energy expenditure. In the present study, the effect of treadmill exercise on the hypothalamic NPY expression in rats with streptozotocin (STZ)-induced diabetes was investigated via immunohistochemistry. Enhanced NPY expression in the paraventricular nucleus and arcuate nucleus was observed in the STZ-induced diabetic rats. Treadmill exercise suppressed a diabetes-induced increase of NPY expression. The present results suggest the possibility that treadmill exercise inhibits diabetes-induced increment of the desire for food.

KW - Arcuate nucleus

KW - Diabetes

KW - Neuropeptide Y

KW - Paraventricular nucleus

KW - Treadmill exercise

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Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats

Abstract

Keywords

ASJC Scopus subject areas

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