Treadmill exercise increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes

Hyun Bae Kim, Mi-Hyeon D Jang, Min Chul Shin, Baek Vin Lim, Young Pyo Kim, Kyung Ji Kim, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Diabetes mellitus is a common and serious metabolic disorder in humans. Streptozotocin (STZ)-induced diabetic rats were shown to produce a significant reduction in the number of proliferating cells in the dentate gyrus. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats with STZ-induced diabetes was investigated via immunohistochemistry. Male Sprague-Dawley rats were divided into four groups: the control-rest group, the control-exercise group, the diabetes-rest group, and the diabetes-exercise group. Each of the animals of the diabetes groups was given a single injection of STZ (50 mg/kg) intraperitoneally. All animals were injected with 5-bromo-2′-deoxyuridine (50 mg/kg) for six consecutive days, starting on the second day after STZ injection, and rats of the exercise groups were made to run on treadmill for 30 min each day over the same period. On the eighth day of the experiment, all animals were sacrificed. In the present results, it was shown that cell proliferation in the dentate gyrus is suppressed under diabetic conditions, and that treadmill is effective in enhancing hippocampal granular cell proliferation in rats with STZ-induced diabetes. These results raise the possibility that treadmill exercise is of help in the alleviation of the central neural sequelae of diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalJournal of Diabetes and its Complications
Volume17
Issue number1
DOIs
StatePublished - Jan 2003
Externally publishedYes

Fingerprint

Experimental Diabetes Mellitus
Dentate Gyrus
Streptozocin
Cell Proliferation
Diabetes Mellitus
Control Groups
Injections
Bromodeoxyuridine
Sprague Dawley Rats
Cell Count
Immunohistochemistry

Keywords

  • 5-Bromo-2′-deoxyuridine
  • Diabetes
  • Streptozotocin
  • Treadmill running

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Treadmill exercise increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes. / Kim, Hyun Bae; Jang, Mi-Hyeon D; Shin, Min Chul; Lim, Baek Vin; Kim, Young Pyo; Kim, Kyung Ji; Kim, Ee Hwa; Kim, Chang Ju.

In: Journal of Diabetes and its Complications, Vol. 17, No. 1, 01.2003, p. 29-33.

Research output: Contribution to journalArticle

Kim, Hyun Bae ; Jang, Mi-Hyeon D ; Shin, Min Chul ; Lim, Baek Vin ; Kim, Young Pyo ; Kim, Kyung Ji ; Kim, Ee Hwa ; Kim, Chang Ju. / Treadmill exercise increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes. In: Journal of Diabetes and its Complications. 2003 ; Vol. 17, No. 1. pp. 29-33.
@article{90454a992eff46a7909ea0d3794f66c6,
title = "Treadmill exercise increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes",
abstract = "Diabetes mellitus is a common and serious metabolic disorder in humans. Streptozotocin (STZ)-induced diabetic rats were shown to produce a significant reduction in the number of proliferating cells in the dentate gyrus. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats with STZ-induced diabetes was investigated via immunohistochemistry. Male Sprague-Dawley rats were divided into four groups: the control-rest group, the control-exercise group, the diabetes-rest group, and the diabetes-exercise group. Each of the animals of the diabetes groups was given a single injection of STZ (50 mg/kg) intraperitoneally. All animals were injected with 5-bromo-2′-deoxyuridine (50 mg/kg) for six consecutive days, starting on the second day after STZ injection, and rats of the exercise groups were made to run on treadmill for 30 min each day over the same period. On the eighth day of the experiment, all animals were sacrificed. In the present results, it was shown that cell proliferation in the dentate gyrus is suppressed under diabetic conditions, and that treadmill is effective in enhancing hippocampal granular cell proliferation in rats with STZ-induced diabetes. These results raise the possibility that treadmill exercise is of help in the alleviation of the central neural sequelae of diabetes mellitus.",
keywords = "5-Bromo-2′-deoxyuridine, Diabetes, Streptozotocin, Treadmill running",
author = "Kim, {Hyun Bae} and Jang, {Mi-Hyeon D} and Shin, {Min Chul} and Lim, {Baek Vin} and Kim, {Young Pyo} and Kim, {Kyung Ji} and Kim, {Ee Hwa} and Kim, {Chang Ju}",
year = "2003",
month = "1",
doi = "10.1016/S1056-8727(02)00186-1",
language = "English (US)",
volume = "17",
pages = "29--33",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Treadmill exercise increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes

AU - Kim, Hyun Bae

AU - Jang, Mi-Hyeon D

AU - Shin, Min Chul

AU - Lim, Baek Vin

AU - Kim, Young Pyo

AU - Kim, Kyung Ji

AU - Kim, Ee Hwa

AU - Kim, Chang Ju

PY - 2003/1

Y1 - 2003/1

N2 - Diabetes mellitus is a common and serious metabolic disorder in humans. Streptozotocin (STZ)-induced diabetic rats were shown to produce a significant reduction in the number of proliferating cells in the dentate gyrus. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats with STZ-induced diabetes was investigated via immunohistochemistry. Male Sprague-Dawley rats were divided into four groups: the control-rest group, the control-exercise group, the diabetes-rest group, and the diabetes-exercise group. Each of the animals of the diabetes groups was given a single injection of STZ (50 mg/kg) intraperitoneally. All animals were injected with 5-bromo-2′-deoxyuridine (50 mg/kg) for six consecutive days, starting on the second day after STZ injection, and rats of the exercise groups were made to run on treadmill for 30 min each day over the same period. On the eighth day of the experiment, all animals were sacrificed. In the present results, it was shown that cell proliferation in the dentate gyrus is suppressed under diabetic conditions, and that treadmill is effective in enhancing hippocampal granular cell proliferation in rats with STZ-induced diabetes. These results raise the possibility that treadmill exercise is of help in the alleviation of the central neural sequelae of diabetes mellitus.

AB - Diabetes mellitus is a common and serious metabolic disorder in humans. Streptozotocin (STZ)-induced diabetic rats were shown to produce a significant reduction in the number of proliferating cells in the dentate gyrus. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats with STZ-induced diabetes was investigated via immunohistochemistry. Male Sprague-Dawley rats were divided into four groups: the control-rest group, the control-exercise group, the diabetes-rest group, and the diabetes-exercise group. Each of the animals of the diabetes groups was given a single injection of STZ (50 mg/kg) intraperitoneally. All animals were injected with 5-bromo-2′-deoxyuridine (50 mg/kg) for six consecutive days, starting on the second day after STZ injection, and rats of the exercise groups were made to run on treadmill for 30 min each day over the same period. On the eighth day of the experiment, all animals were sacrificed. In the present results, it was shown that cell proliferation in the dentate gyrus is suppressed under diabetic conditions, and that treadmill is effective in enhancing hippocampal granular cell proliferation in rats with STZ-induced diabetes. These results raise the possibility that treadmill exercise is of help in the alleviation of the central neural sequelae of diabetes mellitus.

KW - 5-Bromo-2′-deoxyuridine

KW - Diabetes

KW - Streptozotocin

KW - Treadmill running

UR - http://www.scopus.com/inward/record.url?scp=0037224041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037224041&partnerID=8YFLogxK

U2 - 10.1016/S1056-8727(02)00186-1

DO - 10.1016/S1056-8727(02)00186-1

M3 - Article

C2 - 12505754

AN - SCOPUS:0037224041

VL - 17

SP - 29

EP - 33

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 1

ER -