Abstract
Diabetes mellitus is a common and serious metabolic disorder in humans. Streptozotocin (STZ)-induced diabetic rats were shown to produce a significant reduction in the number of proliferating cells in the dentate gyrus. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats with STZ-induced diabetes was investigated via immunohistochemistry. Male Sprague-Dawley rats were divided into four groups: the control-rest group, the control-exercise group, the diabetes-rest group, and the diabetes-exercise group. Each of the animals of the diabetes groups was given a single injection of STZ (50 mg/kg) intraperitoneally. All animals were injected with 5-bromo-2′-deoxyuridine (50 mg/kg) for six consecutive days, starting on the second day after STZ injection, and rats of the exercise groups were made to run on treadmill for 30 min each day over the same period. On the eighth day of the experiment, all animals were sacrificed. In the present results, it was shown that cell proliferation in the dentate gyrus is suppressed under diabetic conditions, and that treadmill is effective in enhancing hippocampal granular cell proliferation in rats with STZ-induced diabetes. These results raise the possibility that treadmill exercise is of help in the alleviation of the central neural sequelae of diabetes mellitus.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 29-33 |
| Number of pages | 5 |
| Journal | Journal of Diabetes and its Complications |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2003 |
| Externally published | Yes |
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Keywords
- 5-Bromo-2′-deoxyuridine
- Diabetes
- Streptozotocin
- Treadmill running
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Treadmill exercise increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes. / Kim, Hyun Bae; Jang, Mi-Hyeon D; Shin, Min Chul; Lim, Baek Vin; Kim, Young Pyo; Kim, Kyung Ji; Kim, Ee Hwa; Kim, Chang Ju.
In: Journal of Diabetes and its Complications, Vol. 17, No. 1, 01.2003, p. 29-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treadmill exercise increases cell proliferation in dentate gyrus of rats with streptozotocin-induced diabetes
AU - Kim, Hyun Bae
AU - Jang, Mi-Hyeon D
AU - Shin, Min Chul
AU - Lim, Baek Vin
AU - Kim, Young Pyo
AU - Kim, Kyung Ji
AU - Kim, Ee Hwa
AU - Kim, Chang Ju
PY - 2003/1
Y1 - 2003/1
N2 - Diabetes mellitus is a common and serious metabolic disorder in humans. Streptozotocin (STZ)-induced diabetic rats were shown to produce a significant reduction in the number of proliferating cells in the dentate gyrus. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats with STZ-induced diabetes was investigated via immunohistochemistry. Male Sprague-Dawley rats were divided into four groups: the control-rest group, the control-exercise group, the diabetes-rest group, and the diabetes-exercise group. Each of the animals of the diabetes groups was given a single injection of STZ (50 mg/kg) intraperitoneally. All animals were injected with 5-bromo-2′-deoxyuridine (50 mg/kg) for six consecutive days, starting on the second day after STZ injection, and rats of the exercise groups were made to run on treadmill for 30 min each day over the same period. On the eighth day of the experiment, all animals were sacrificed. In the present results, it was shown that cell proliferation in the dentate gyrus is suppressed under diabetic conditions, and that treadmill is effective in enhancing hippocampal granular cell proliferation in rats with STZ-induced diabetes. These results raise the possibility that treadmill exercise is of help in the alleviation of the central neural sequelae of diabetes mellitus.
AB - Diabetes mellitus is a common and serious metabolic disorder in humans. Streptozotocin (STZ)-induced diabetic rats were shown to produce a significant reduction in the number of proliferating cells in the dentate gyrus. In the present study, the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats with STZ-induced diabetes was investigated via immunohistochemistry. Male Sprague-Dawley rats were divided into four groups: the control-rest group, the control-exercise group, the diabetes-rest group, and the diabetes-exercise group. Each of the animals of the diabetes groups was given a single injection of STZ (50 mg/kg) intraperitoneally. All animals were injected with 5-bromo-2′-deoxyuridine (50 mg/kg) for six consecutive days, starting on the second day after STZ injection, and rats of the exercise groups were made to run on treadmill for 30 min each day over the same period. On the eighth day of the experiment, all animals were sacrificed. In the present results, it was shown that cell proliferation in the dentate gyrus is suppressed under diabetic conditions, and that treadmill is effective in enhancing hippocampal granular cell proliferation in rats with STZ-induced diabetes. These results raise the possibility that treadmill exercise is of help in the alleviation of the central neural sequelae of diabetes mellitus.
KW - 5-Bromo-2′-deoxyuridine
KW - Diabetes
KW - Streptozotocin
KW - Treadmill running
UR - http://www.scopus.com/inward/record.url?scp=0037224041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037224041&partnerID=8YFLogxK
U2 - 10.1016/S1056-8727(02)00186-1
DO - 10.1016/S1056-8727(02)00186-1
M3 - Article
C2 - 12505754
AN - SCOPUS:0037224041
VL - 17
SP - 29
EP - 33
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 1
ER -