Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: A united states multicenter study

Bruce H. Haughey; Michael L. Hinni; John R. Salassa; Richard E. Hayden; David G. Grant; Jason T. Rich; Simon Milov; James S. Lewis; Murli Krishna

doi:10.1002/hed.21669

Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: A united states multicenter study

Bruce H. Haughey, Michael L. Hinni, John R. Salassa, Richard E. Hayden, David G. Grant, Jason T. Rich, Simon Milov, James S. Lewis, Murli Krishna

Research output: Contribution to journal › Article › peer-review

257 Scopus citations

Abstract

Background Nonsurgical modalities are sometimes advocated as the standard of care for advanced oropharyngeal tumors. Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma. Methods A prospectively assembled database of 204 patients with American Joint Committee on Cancer (AJCC) stages III and IV tonsil or tongue base cancer, treated primarily with TLM during 1996-2006 at 3 centers with minimum 2-year follow-up was analyzed. Survival, locoregional control, and swallowing status were recorded. Results Mean follow-up was 49 months and 79.4% of patients were alive. Three-year overall survival, disease-specific survival, and disease-free survival were 86%, 88%, and 82%, respectively. Local control was 97%, and 87% of patients had normal swallowing or episodic dysphagia. Conclusions TLM as a primary treatment for advanced oropharyngeal malignancy confers excellent survival and swallowing proficiency.

Original language	English (US)
Pages (from-to)	1683-1694
Number of pages	12
Journal	Head and Neck
Volume	33
Issue number	12
DOIs	https://doi.org/10.1002/hed.21669
State	Published - Dec 2011

Keywords

base of tongue cancer
human papillomavirus
laser
minimally invasive
tonsil cancer

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.21669

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title = "Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: A united states multicenter study",

abstract = "Background Nonsurgical modalities are sometimes advocated as the standard of care for advanced oropharyngeal tumors. Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma. Methods A prospectively assembled database of 204 patients with American Joint Committee on Cancer (AJCC) stages III and IV tonsil or tongue base cancer, treated primarily with TLM during 1996-2006 at 3 centers with minimum 2-year follow-up was analyzed. Survival, locoregional control, and swallowing status were recorded. Results Mean follow-up was 49 months and 79.4% of patients were alive. Three-year overall survival, disease-specific survival, and disease-free survival were 86%, 88%, and 82%, respectively. Local control was 97%, and 87% of patients had normal swallowing or episodic dysphagia. Conclusions TLM as a primary treatment for advanced oropharyngeal malignancy confers excellent survival and swallowing proficiency.",

keywords = "base of tongue cancer, human papillomavirus, laser, minimally invasive, tonsil cancer",

author = "Haughey, {Bruce H.} and Hinni, {Michael L.} and Salassa, {John R.} and Hayden, {Richard E.} and Grant, {David G.} and Rich, {Jason T.} and Simon Milov and Lewis, {James S.} and Murli Krishna",

year = "2011",

month = dec,

doi = "10.1002/hed.21669",

language = "English (US)",

volume = "33",

pages = "1683--1694",

journal = "Head and Neck",

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T1 - Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer

T2 - A united states multicenter study

AU - Haughey, Bruce H.

AU - Hinni, Michael L.

AU - Salassa, John R.

AU - Hayden, Richard E.

AU - Grant, David G.

AU - Rich, Jason T.

AU - Milov, Simon

AU - Lewis, James S.

AU - Krishna, Murli

PY - 2011/12

Y1 - 2011/12

N2 - Background Nonsurgical modalities are sometimes advocated as the standard of care for advanced oropharyngeal tumors. Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma. Methods A prospectively assembled database of 204 patients with American Joint Committee on Cancer (AJCC) stages III and IV tonsil or tongue base cancer, treated primarily with TLM during 1996-2006 at 3 centers with minimum 2-year follow-up was analyzed. Survival, locoregional control, and swallowing status were recorded. Results Mean follow-up was 49 months and 79.4% of patients were alive. Three-year overall survival, disease-specific survival, and disease-free survival were 86%, 88%, and 82%, respectively. Local control was 97%, and 87% of patients had normal swallowing or episodic dysphagia. Conclusions TLM as a primary treatment for advanced oropharyngeal malignancy confers excellent survival and swallowing proficiency.

AB - Background Nonsurgical modalities are sometimes advocated as the standard of care for advanced oropharyngeal tumors. Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma. Methods A prospectively assembled database of 204 patients with American Joint Committee on Cancer (AJCC) stages III and IV tonsil or tongue base cancer, treated primarily with TLM during 1996-2006 at 3 centers with minimum 2-year follow-up was analyzed. Survival, locoregional control, and swallowing status were recorded. Results Mean follow-up was 49 months and 79.4% of patients were alive. Three-year overall survival, disease-specific survival, and disease-free survival were 86%, 88%, and 82%, respectively. Local control was 97%, and 87% of patients had normal swallowing or episodic dysphagia. Conclusions TLM as a primary treatment for advanced oropharyngeal malignancy confers excellent survival and swallowing proficiency.

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KW - human papillomavirus

KW - laser

KW - minimally invasive

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Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: A united states multicenter study

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