Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer

A united states multicenter study

Bruce H. Haughey, Michael L. Hinni, John R. Salassa, Richard E Hayden, David G. Grant, Jason T. Rich, Simon Milov, James S. Lewis, Murli Krishna

Research output: Contribution to journalArticle

221 Citations (Scopus)

Abstract

Background Nonsurgical modalities are sometimes advocated as the standard of care for advanced oropharyngeal tumors. Oncologic and functional results have been modest. The aim of our study was to evaluate outcomes of a minimally invasive approach, using transoral laser microsurgery (TLM) as the primary treatment for advanced oropharyngeal carcinoma. Methods A prospectively assembled database of 204 patients with American Joint Committee on Cancer (AJCC) stages III and IV tonsil or tongue base cancer, treated primarily with TLM during 1996-2006 at 3 centers with minimum 2-year follow-up was analyzed. Survival, locoregional control, and swallowing status were recorded. Results Mean follow-up was 49 months and 79.4% of patients were alive. Three-year overall survival, disease-specific survival, and disease-free survival were 86%, 88%, and 82%, respectively. Local control was 97%, and 87% of patients had normal swallowing or episodic dysphagia. Conclusions TLM as a primary treatment for advanced oropharyngeal malignancy confers excellent survival and swallowing proficiency.

Original languageEnglish (US)
Pages (from-to)1683-1694
Number of pages12
JournalHead and Neck
Volume33
Issue number12
DOIs
StatePublished - Dec 2011

Fingerprint

Oropharyngeal Neoplasms
Microsurgery
Multicenter Studies
Lasers
Deglutition
Survival
Tongue Neoplasms
Neoplasms
Palatine Tonsil
Therapeutics
Standard of Care
Deglutition Disorders
Disease-Free Survival
Databases
Carcinoma

Keywords

  • base of tongue cancer
  • human papillomavirus
  • laser
  • minimally invasive
  • tonsil cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer : A united states multicenter study. / Haughey, Bruce H.; Hinni, Michael L.; Salassa, John R.; Hayden, Richard E; Grant, David G.; Rich, Jason T.; Milov, Simon; Lewis, James S.; Krishna, Murli.

In: Head and Neck, Vol. 33, No. 12, 12.2011, p. 1683-1694.

Research output: Contribution to journalArticle

Haughey, BH, Hinni, ML, Salassa, JR, Hayden, RE, Grant, DG, Rich, JT, Milov, S, Lewis, JS & Krishna, M 2011, 'Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer: A united states multicenter study', Head and Neck, vol. 33, no. 12, pp. 1683-1694. https://doi.org/10.1002/hed.21669
Haughey, Bruce H. ; Hinni, Michael L. ; Salassa, John R. ; Hayden, Richard E ; Grant, David G. ; Rich, Jason T. ; Milov, Simon ; Lewis, James S. ; Krishna, Murli. / Transoral laser microsurgery as primary treatment for advanced-stage oropharyngeal cancer : A united states multicenter study. In: Head and Neck. 2011 ; Vol. 33, No. 12. pp. 1683-1694.
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