TY - JOUR
T1 - Transfusion-related acute lung injury
AU - Toy, Pearl
AU - Gajic, Ognjen
PY - 2004/12
Y1 - 2004/12
N2 - Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. It is characterized by injury to the alveolar-capillary membrane precipitated by transfusion factors, antibodies, and/or inflammatory mediators, in a susceptible host. In the absence of a specific test, TRALI is defined clinically as a syndrome of acute lung injury that develops during or within 6 h of transfusion. The absence of left atrial hypertension and large protein content of edema fluid may help differentiate TRALI from hydrostatic pulmonary edema. The treatment is supportive. The blood bank needs to be notified promptly so that an appropriate workup and prevention are initiated in a timely manner.
AB - Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. It is characterized by injury to the alveolar-capillary membrane precipitated by transfusion factors, antibodies, and/or inflammatory mediators, in a susceptible host. In the absence of a specific test, TRALI is defined clinically as a syndrome of acute lung injury that develops during or within 6 h of transfusion. The absence of left atrial hypertension and large protein content of edema fluid may help differentiate TRALI from hydrostatic pulmonary edema. The treatment is supportive. The blood bank needs to be notified promptly so that an appropriate workup and prevention are initiated in a timely manner.
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U2 - 10.1213/01.ANE.0000138033.24633.4E
DO - 10.1213/01.ANE.0000138033.24633.4E
M3 - Article
C2 - 15562043
AN - SCOPUS:9244244785
SN - 0003-2999
VL - 99
SP - 1623
EP - 1624
JO - Anesthesia and analgesia
JF - Anesthesia and analgesia
IS - 6
ER -