Transcriptional control of osteoblast growth and differentiation

Gary S. Stein, Jane B. Lian, Janet L. Stein, André J. Van Wijnen, Martin Montecino

Research output: Contribution to journalReview article

370 Scopus citations

Abstract

Osteoblast differentiation is a multistep series of events modulated by an integrated cascade of gene expression that initially supports proliferation and the sequential expression of genes associated with the biosynthesis, organization, and mineralization of the bone extracellular matrix. Transcriptional control defines regulatory events operative both developmentally and for support of bone tissue-specific properties. This review focuses on components of transcriptional regulation that function in growth control during osteoblast proliferation and those that postproliferatively contribute to maturation of the bone phenotype. Emphasis is on transcription of the cell cycle-regulated histone gene and the bone-specific osteocalcin gene as paradigms for genes with promoter elements exhibiting responsiveness to a broad spectrum of physiological regulatory signals. Additionally, the potential contributions provided by the three-dimensional organization of the histone and osteocalcin gene promoters to integration of regulatory activities at multiple, independent, and overlapping regulatory domains are explored.

Original languageEnglish (US)
Pages (from-to)593-629
Number of pages37
JournalPhysiological Reviews
Volume76
Issue number2
DOIs
StatePublished - Apr 1996

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Physiology (medical)

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    Stein, G. S., Lian, J. B., Stein, J. L., Van Wijnen, A. J., & Montecino, M. (1996). Transcriptional control of osteoblast growth and differentiation. Physiological Reviews, 76(2), 593-629. https://doi.org/10.1152/physrev.1996.76.2.593