Transcriptional control: An essential component of cancer gene therapy strategies?

Kevin J. Harrington, Emmanouela Linardakis, Richard Geoffrey Vile

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The therapeutic index of cancer gene therapy approaches will, at least in part, be dictated by the spatial and temporal control of expression of the therapeutic transgenes. Strategies which allow precise control of gene transcription are likely to play a crucial role in the future pre-clinical and clinical development of gene therapy. In this review, we discuss these issues as they relate to tissue and tumor specific promoters. In addition, the exciting opportunities offered by the development of regulated gene expression systems using small molecules, radiation and heat are reviewed. It is realistic to expect that the future offers the prospect of amalgamating elements of a number of these different systems in a co-ordinated gene delivery approach with the potential to increase the efficacy and reduce the toxicity of treatment. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)167-184
Number of pages18
JournalAdvanced Drug Delivery Reviews
Volume44
Issue number2-3
DOIs
StatePublished - Nov 15 2000

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Keywords

  • Customized promoter
  • Enhancer
  • Gene therapy
  • Inducible promoter
  • Tissue specific promoter
  • Tumor specific promoter

ASJC Scopus subject areas

  • Pharmaceutical Science

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