Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders

Jose Lujan, Ashutosh Chaturvedi, Cameron C. McIntyre

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) has recently emerged as a potential treatment for medically intractable neuropsychiatric disorders. Pilot clinical studies with encouraging results have been performed with DBS of the ventral anterior internal capsule (VAIC) and subgenual cingulate white matter (Cg25WM) for the treatment of obsessive-compulsive disorder and depression. However, little is known about the underlying response of individual neurons, or the networks they are connected to, when DBS is applied to the VAIC or Cg25WM. This review summarizes current understanding of the response of axons to DBS, and discusses the general brain network architectures thought to underlie neuropsychiatric disorders. We also employ diffusion tensor imaging tractography to better understand the axonal trajectories surrounding DBS electrodes implanted in the VAIC or Cg25WM. Finally, we attempt to reconcile various data sets by presenting generalized hypotheses on potential therapeutic mechanisms of DBS for neuropsychiatric disease.

Original languageEnglish (US)
Pages (from-to)5892-5904
Number of pages13
JournalFrontiers in Bioscience
Volume13
Issue number15
DOIs
StatePublished - May 1 2008
Externally publishedYes

Fingerprint

Deep Brain Stimulation
Brain
Internal Capsule
Capsules
Implanted Electrodes
Diffusion tensor imaging
Diffusion Tensor Imaging
Obsessive-Compulsive Disorder
Axons
Network architecture
Therapeutics
Neurons
Depression
Trajectories
Electrodes

Keywords

  • Deep Brain Stimulation
  • Depression
  • Neuromodulation
  • Neurostimulation
  • Obsessive Compulsive Disorder
  • Psychiatric Disorders
  • Review
  • Tractography

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders. / Lujan, Jose; Chaturvedi, Ashutosh; McIntyre, Cameron C.

In: Frontiers in Bioscience, Vol. 13, No. 15, 01.05.2008, p. 5892-5904.

Research output: Contribution to journalReview article

Lujan, Jose ; Chaturvedi, Ashutosh ; McIntyre, Cameron C. / Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders. In: Frontiers in Bioscience. 2008 ; Vol. 13, No. 15. pp. 5892-5904.
@article{fde414c553a24a74bbc61260c8adef63,
title = "Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders",
abstract = "Deep brain stimulation (DBS) has recently emerged as a potential treatment for medically intractable neuropsychiatric disorders. Pilot clinical studies with encouraging results have been performed with DBS of the ventral anterior internal capsule (VAIC) and subgenual cingulate white matter (Cg25WM) for the treatment of obsessive-compulsive disorder and depression. However, little is known about the underlying response of individual neurons, or the networks they are connected to, when DBS is applied to the VAIC or Cg25WM. This review summarizes current understanding of the response of axons to DBS, and discusses the general brain network architectures thought to underlie neuropsychiatric disorders. We also employ diffusion tensor imaging tractography to better understand the axonal trajectories surrounding DBS electrodes implanted in the VAIC or Cg25WM. Finally, we attempt to reconcile various data sets by presenting generalized hypotheses on potential therapeutic mechanisms of DBS for neuropsychiatric disease.",
keywords = "Deep Brain Stimulation, Depression, Neuromodulation, Neurostimulation, Obsessive Compulsive Disorder, Psychiatric Disorders, Review, Tractography",
author = "Jose Lujan and Ashutosh Chaturvedi and McIntyre, {Cameron C.}",
year = "2008",
month = "5",
day = "1",
doi = "10.2741/3124",
language = "English (US)",
volume = "13",
pages = "5892--5904",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",
number = "15",

}

TY - JOUR

T1 - Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders

AU - Lujan, Jose

AU - Chaturvedi, Ashutosh

AU - McIntyre, Cameron C.

PY - 2008/5/1

Y1 - 2008/5/1

N2 - Deep brain stimulation (DBS) has recently emerged as a potential treatment for medically intractable neuropsychiatric disorders. Pilot clinical studies with encouraging results have been performed with DBS of the ventral anterior internal capsule (VAIC) and subgenual cingulate white matter (Cg25WM) for the treatment of obsessive-compulsive disorder and depression. However, little is known about the underlying response of individual neurons, or the networks they are connected to, when DBS is applied to the VAIC or Cg25WM. This review summarizes current understanding of the response of axons to DBS, and discusses the general brain network architectures thought to underlie neuropsychiatric disorders. We also employ diffusion tensor imaging tractography to better understand the axonal trajectories surrounding DBS electrodes implanted in the VAIC or Cg25WM. Finally, we attempt to reconcile various data sets by presenting generalized hypotheses on potential therapeutic mechanisms of DBS for neuropsychiatric disease.

AB - Deep brain stimulation (DBS) has recently emerged as a potential treatment for medically intractable neuropsychiatric disorders. Pilot clinical studies with encouraging results have been performed with DBS of the ventral anterior internal capsule (VAIC) and subgenual cingulate white matter (Cg25WM) for the treatment of obsessive-compulsive disorder and depression. However, little is known about the underlying response of individual neurons, or the networks they are connected to, when DBS is applied to the VAIC or Cg25WM. This review summarizes current understanding of the response of axons to DBS, and discusses the general brain network architectures thought to underlie neuropsychiatric disorders. We also employ diffusion tensor imaging tractography to better understand the axonal trajectories surrounding DBS electrodes implanted in the VAIC or Cg25WM. Finally, we attempt to reconcile various data sets by presenting generalized hypotheses on potential therapeutic mechanisms of DBS for neuropsychiatric disease.

KW - Deep Brain Stimulation

KW - Depression

KW - Neuromodulation

KW - Neurostimulation

KW - Obsessive Compulsive Disorder

KW - Psychiatric Disorders

KW - Review

KW - Tractography

UR - http://www.scopus.com/inward/record.url?scp=52049105593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52049105593&partnerID=8YFLogxK

U2 - 10.2741/3124

DO - 10.2741/3124

M3 - Review article

C2 - 18508630

AN - SCOPUS:52049105593

VL - 13

SP - 5892

EP - 5904

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

IS - 15

ER -