Total intracranial volume: Normative values and lack of association with Alzheimer's disease

S. D. Edland; Y. Xu; M. Plevak; P. O'Brien; E. G. Tangalos; R. C. Petersen; C. R. Jack

doi:10.1212/WNL.59.2.272

Total intracranial volume: Normative values and lack of association with Alzheimer's disease

S. D. Edland, Y. Xu, M. Plevak, P. O'Brien, E. G. Tangalos, R. C. Petersen, C. R. Jack

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

A larger premorbid brain is hypothesized to provide neuronal reserve against AD. Using MRI data from ongoing studies of normal aging and AD, the authors tested this hypothesis. Mean total intracranial volume was 15.8 cm³ smaller for cases among women (n = 121 normal and 104 AD; p = 0.24) and 10.1 cm³ larger for cases among men (n = 63 normal and 62 AD; p = 0.59). These differences are small and nonsignificant, suggesting that head size per se is not a critical determinant of AD.

Original language	English (US)
Pages (from-to)	272-274
Number of pages	3
Journal	Neurology
Volume	59
Issue number	2
DOIs	https://doi.org/10.1212/WNL.59.2.272
State	Published - Jul 23 2002

ASJC Scopus subject areas

Clinical Neurology

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abstract = "A larger premorbid brain is hypothesized to provide neuronal reserve against AD. Using MRI data from ongoing studies of normal aging and AD, the authors tested this hypothesis. Mean total intracranial volume was 15.8 cm3 smaller for cases among women (n = 121 normal and 104 AD; p = 0.24) and 10.1 cm3 larger for cases among men (n = 63 normal and 62 AD; p = 0.59). These differences are small and nonsignificant, suggesting that head size per se is not a critical determinant of AD.",

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AU - Plevak, M.

AU - O'Brien, P.

AU - Tangalos, E. G.

AU - Petersen, R. C.

AU - Jack, C. R.

PY - 2002/7/23

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AB - A larger premorbid brain is hypothesized to provide neuronal reserve against AD. Using MRI data from ongoing studies of normal aging and AD, the authors tested this hypothesis. Mean total intracranial volume was 15.8 cm3 smaller for cases among women (n = 121 normal and 104 AD; p = 0.24) and 10.1 cm3 larger for cases among men (n = 63 normal and 62 AD; p = 0.59). These differences are small and nonsignificant, suggesting that head size per se is not a critical determinant of AD.

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Total intracranial volume: Normative values and lack of association with Alzheimer's disease

Abstract

ASJC Scopus subject areas

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