Topoisomerase II as a target for anticancer chemotherapy.

Scott H Kaufmann, R. Hancock

Research output: Contribution to journalArticle

Abstract

Type II DNA topoisomerases are required for the segregation of genomic DNA at cell division in prokaryotic and eukaryotic cells, and inhibitors of these enzymes are potential cytotoxic agents in both prokaryotes and eukaryotes. The bacterial member of the topoisomerase II family, DNA gyrase, and the chemotherapeutic agents which target it are the subject of a recent review (Maxwell, A. et al., 1993, in Molecular Biology of DNA Topoisomerases, Andoh, T. et al., eds., pp. 21-30, CRC Press, Boca Raton). Here we present an overview of current knowledge of eukaryotic topoisomerase II and the anticancer agents which target this enzyme, focussing predominantly on new observations and recent reports and reviews.

Original languageEnglish (US)
Pages (from-to)381-393
Number of pages13
JournalActa Biochimica Polonica
Volume42
Issue number4
StatePublished - 1995

Fingerprint

Type II DNA Topoisomerase
Chemotherapy
Drug Therapy
DNA Topoisomerases
Prokaryotic Cells
DNA Gyrase
Molecular biology
Cytotoxins
Eukaryotic Cells
Enzyme Inhibitors
Eukaryota
Cell Division
Antineoplastic Agents
Molecular Biology
Cells
DNA
Enzymes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Topoisomerase II as a target for anticancer chemotherapy. / Kaufmann, Scott H; Hancock, R.

In: Acta Biochimica Polonica, Vol. 42, No. 4, 1995, p. 381-393.

Research output: Contribution to journalArticle

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