Abstract
Objective: To describe the clinical features of patients with eosinophilic esophagitis and the use of topical corticosteroids for treatment. Patients and Methods: We evaluated the charts of 21 patients with a diagnosis of eosinophilic esophagitis seen at the Mayo Clinic in Rochester, Minn, between September 1, 1999, and December 31, 2001. The diagnosis was based on the presence of a "ringed esophagus" or a tapered distal esophagus on upper endoscopy as well as the presence of a dense eosinophilic infiltrate on esophageal biopsy. All patients were treated with topical corticosteroids, and follow-up was performed by telephone interviews. Results: The 17 men and 4 women ranged in age from 28 years to 55 years at diagnosis (mean, 40 years). All had solid-food dysphagia for at least 6 years, and 15 patients had prior food impaction. Eighteen patients had either a ringed-appearing esophagus or smooth tapering in the distal esophagus. All patients had a dense eosinophilic infiltration (>20 eosinophils per high-power field) in the mid or distal esophagus. Topical corticosteroid therapy for 6 weeks resulted in complete dysphagia relief in all patients and lasted a minimum of 4 months. Conclusion: Eosinophilic esophagitis is an entity associated with food dysphagia (predominantly in young adults) and a ringed or smooth tapered distal-appearing esophagus. Our study found no association with gastroesophageal reflux symptoms. Topical corticosteroid therapy was effective.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 830-835 |
| Number of pages | 6 |
| Journal | Mayo Clinic Proceedings |
| Volume | 78 |
| Issue number | 7 |
| State | Published - Jul 1 2003 |
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ASJC Scopus subject areas
- Medicine(all)
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Topical corticosteroid treatment of dysphagia due to eosinophilic esophagitis in adults. / Arora, Amindra S.; Perrault, Jean; Smyrk, Thomas Christopher.
In: Mayo Clinic Proceedings, Vol. 78, No. 7, 01.07.2003, p. 830-835.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Topical corticosteroid treatment of dysphagia due to eosinophilic esophagitis in adults
AU - Arora, Amindra S.
AU - Perrault, Jean
AU - Smyrk, Thomas Christopher
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Objective: To describe the clinical features of patients with eosinophilic esophagitis and the use of topical corticosteroids for treatment. Patients and Methods: We evaluated the charts of 21 patients with a diagnosis of eosinophilic esophagitis seen at the Mayo Clinic in Rochester, Minn, between September 1, 1999, and December 31, 2001. The diagnosis was based on the presence of a "ringed esophagus" or a tapered distal esophagus on upper endoscopy as well as the presence of a dense eosinophilic infiltrate on esophageal biopsy. All patients were treated with topical corticosteroids, and follow-up was performed by telephone interviews. Results: The 17 men and 4 women ranged in age from 28 years to 55 years at diagnosis (mean, 40 years). All had solid-food dysphagia for at least 6 years, and 15 patients had prior food impaction. Eighteen patients had either a ringed-appearing esophagus or smooth tapering in the distal esophagus. All patients had a dense eosinophilic infiltration (>20 eosinophils per high-power field) in the mid or distal esophagus. Topical corticosteroid therapy for 6 weeks resulted in complete dysphagia relief in all patients and lasted a minimum of 4 months. Conclusion: Eosinophilic esophagitis is an entity associated with food dysphagia (predominantly in young adults) and a ringed or smooth tapered distal-appearing esophagus. Our study found no association with gastroesophageal reflux symptoms. Topical corticosteroid therapy was effective.
AB - Objective: To describe the clinical features of patients with eosinophilic esophagitis and the use of topical corticosteroids for treatment. Patients and Methods: We evaluated the charts of 21 patients with a diagnosis of eosinophilic esophagitis seen at the Mayo Clinic in Rochester, Minn, between September 1, 1999, and December 31, 2001. The diagnosis was based on the presence of a "ringed esophagus" or a tapered distal esophagus on upper endoscopy as well as the presence of a dense eosinophilic infiltrate on esophageal biopsy. All patients were treated with topical corticosteroids, and follow-up was performed by telephone interviews. Results: The 17 men and 4 women ranged in age from 28 years to 55 years at diagnosis (mean, 40 years). All had solid-food dysphagia for at least 6 years, and 15 patients had prior food impaction. Eighteen patients had either a ringed-appearing esophagus or smooth tapering in the distal esophagus. All patients had a dense eosinophilic infiltration (>20 eosinophils per high-power field) in the mid or distal esophagus. Topical corticosteroid therapy for 6 weeks resulted in complete dysphagia relief in all patients and lasted a minimum of 4 months. Conclusion: Eosinophilic esophagitis is an entity associated with food dysphagia (predominantly in young adults) and a ringed or smooth tapered distal-appearing esophagus. Our study found no association with gastroesophageal reflux symptoms. Topical corticosteroid therapy was effective.
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M3 - Article
VL - 78
SP - 830
EP - 835
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 7
ER -