Tissue plasminogen activator (tPA) in acute ischaemic stroke: Time for collegiate communication and consensus

Christopher R. Levi; David J. Blacker; Christopher F. Bladin; Peters M. Boers; Brian R. Chambers; Laurence L. Chu; Alastair J. Corbett; Denis S. Crimmins; Stephen M. Davis; Geoffrey A. Donnan; David W. Dunbabin; John N. Fink; Judith H. Frayne; Richard P. Gerraty; Graeme J. Hankey; Suzanne J. Hodgkinson; James T. Hughes; Tim J. Ingall; Peter B. Landau; Richard I. Lindley; Paul W. Long; Romesh Markus; Elizabeth M. Mullins; Mark W. Parsons; Michael R.P. Pollack; Stephen J. Read; David M. Rosen; David W. Schultz; David E. Serisier; John D.G. Watson; Catherine E. Storey; Alessandro A. Zagami

doi:10.5694/j.1326-5377.2004.tb06127.x

Tissue plasminogen activator (tPA) in acute ischaemic stroke: Time for collegiate communication and consensus

Christopher R. Levi, David J. Blacker, Christopher F. Bladin, Peters M. Boers, Brian R. Chambers, Laurence L. Chu, Alastair J. Corbett, Denis S. Crimmins, Stephen M. Davis, Geoffrey A. Donnan, David W. Dunbabin, John N. Fink, Judith H. Frayne, Richard P. Gerraty, Graeme J. Hankey, Suzanne J. Hodgkinson, James T. Hughes, Tim J. Ingall, Peter B. Landau, Richard I. LindleyPaul W. Long, Romesh Markus, Elizabeth M. Mullins, Mark W. Parsons, Michael R.P. Pollack, Stephen J. Read, David M. Rosen, David W. Schultz, David E. Serisier, John D.G. Watson, Catherine E. Storey, Alessandro A. Zagami

Neurology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

■ Systematic reviews of randomised trials of tPA in acute ischaemic stroke indicate a clear benefit of treating selected patients within 3 hours of stroke onset. Moreover, a net benefit remained after adjustment for chance baseline imbalances between subgroups in stroke severity within one of these trials (National Institute of Neurological Disorders and Stroke [NINDS]). ■ Rates of favourable outcomes and intracranial haemorrhage comparable with those in randomised trials can be achieved in routine clinical practice; however, translation of net benefit from tPA therapy requires organised and coordinated stroke management across the continuum of care. ■ Prerequisites for well organised and coordinated acute stroke care are: consensus among care providers on the use of tPA; stroke-care teams spanning the gaps between pre-hospital care, emergency departments and stroke units; and collegiate relations and effective communication networks between care providers.

Original language	English (US)
Pages (from-to)	634-636
Number of pages	3
Journal	Medical Journal of Australia
Volume	180
Issue number	12
DOIs	https://doi.org/10.5694/j.1326-5377.2004.tb06127.x
State	Published - Jun 21 2004

ASJC Scopus subject areas

General Medicine

Access to Document

10.5694/j.1326-5377.2004.tb06127.x

Cite this

Levi, C. R., Blacker, D. J., Bladin, C. F., Boers, P. M., Chambers, B. R., Chu, L. L., Corbett, A. J., Crimmins, D. S., Davis, S. M., Donnan, G. A., Dunbabin, D. W., Fink, J. N., Frayne, J. H., Gerraty, R. P., Hankey, G. J., Hodgkinson, S. J., Hughes, J. T., Ingall, T. J., Landau, P. B., ... Zagami, A. A. (2004). Tissue plasminogen activator (tPA) in acute ischaemic stroke: Time for collegiate communication and consensus. Medical Journal of Australia, 180(12), 634-636. https://doi.org/10.5694/j.1326-5377.2004.tb06127.x

Levi, CR, Blacker, DJ, Bladin, CF, Boers, PM, Chambers, BR, Chu, LL, Corbett, AJ, Crimmins, DS, Davis, SM, Donnan, GA, Dunbabin, DW, Fink, JN, Frayne, JH, Gerraty, RP, Hankey, GJ, Hodgkinson, SJ, Hughes, JT, Ingall, TJ, Landau, PB, Lindley, RI, Long, PW, Markus, R, Mullins, EM, Parsons, MW, Pollack, MRP, Read, SJ, Rosen, DM, Schultz, DW, Serisier, DE, Watson, JDG, Storey, CE & Zagami, AA 2004, 'Tissue plasminogen activator (tPA) in acute ischaemic stroke: Time for collegiate communication and consensus', Medical Journal of Australia, vol. 180, no. 12, pp. 634-636. https://doi.org/10.5694/j.1326-5377.2004.tb06127.x

@article{c95b5c4dcd764174812464b01d956ac6,

title = "Tissue plasminogen activator (tPA) in acute ischaemic stroke: Time for collegiate communication and consensus",

abstract = "■ Systematic reviews of randomised trials of tPA in acute ischaemic stroke indicate a clear benefit of treating selected patients within 3 hours of stroke onset. Moreover, a net benefit remained after adjustment for chance baseline imbalances between subgroups in stroke severity within one of these trials (National Institute of Neurological Disorders and Stroke [NINDS]). ■ Rates of favourable outcomes and intracranial haemorrhage comparable with those in randomised trials can be achieved in routine clinical practice; however, translation of net benefit from tPA therapy requires organised and coordinated stroke management across the continuum of care. ■ Prerequisites for well organised and coordinated acute stroke care are: consensus among care providers on the use of tPA; stroke-care teams spanning the gaps between pre-hospital care, emergency departments and stroke units; and collegiate relations and effective communication networks between care providers.",

author = "Levi, {Christopher R.} and Blacker, {David J.} and Bladin, {Christopher F.} and Boers, {Peters M.} and Chambers, {Brian R.} and Chu, {Laurence L.} and Corbett, {Alastair J.} and Crimmins, {Denis S.} and Davis, {Stephen M.} and Donnan, {Geoffrey A.} and Dunbabin, {David W.} and Fink, {John N.} and Frayne, {Judith H.} and Gerraty, {Richard P.} and Hankey, {Graeme J.} and Hodgkinson, {Suzanne J.} and Hughes, {James T.} and Ingall, {Tim J.} and Landau, {Peter B.} and Lindley, {Richard I.} and Long, {Paul W.} and Romesh Markus and Mullins, {Elizabeth M.} and Parsons, {Mark W.} and Pollack, {Michael R.P.} and Read, {Stephen J.} and Rosen, {David M.} and Schultz, {David W.} and Serisier, {David E.} and Watson, {John D.G.} and Storey, {Catherine E.} and Zagami, {Alessandro A.}",

year = "2004",

month = jun,

day = "21",

doi = "10.5694/j.1326-5377.2004.tb06127.x",

language = "English (US)",

volume = "180",

pages = "634--636",

journal = "Medical Journal of Australia",

issn = "0025-729X",

publisher = "Australasian Medical Publishing Co. Ltd",

number = "12",

}

TY - JOUR

T1 - Tissue plasminogen activator (tPA) in acute ischaemic stroke

T2 - Time for collegiate communication and consensus

AU - Levi, Christopher R.

AU - Blacker, David J.

AU - Bladin, Christopher F.

AU - Boers, Peters M.

AU - Chambers, Brian R.

AU - Chu, Laurence L.

AU - Corbett, Alastair J.

AU - Crimmins, Denis S.

AU - Davis, Stephen M.

AU - Donnan, Geoffrey A.

AU - Dunbabin, David W.

AU - Fink, John N.

AU - Frayne, Judith H.

AU - Gerraty, Richard P.

AU - Hankey, Graeme J.

AU - Hodgkinson, Suzanne J.

AU - Hughes, James T.

AU - Ingall, Tim J.

AU - Landau, Peter B.

AU - Lindley, Richard I.

AU - Long, Paul W.

AU - Markus, Romesh

AU - Mullins, Elizabeth M.

AU - Parsons, Mark W.

AU - Pollack, Michael R.P.

AU - Read, Stephen J.

AU - Rosen, David M.

AU - Schultz, David W.

AU - Serisier, David E.

AU - Watson, John D.G.

AU - Storey, Catherine E.

AU - Zagami, Alessandro A.

PY - 2004/6/21

Y1 - 2004/6/21

N2 - ■ Systematic reviews of randomised trials of tPA in acute ischaemic stroke indicate a clear benefit of treating selected patients within 3 hours of stroke onset. Moreover, a net benefit remained after adjustment for chance baseline imbalances between subgroups in stroke severity within one of these trials (National Institute of Neurological Disorders and Stroke [NINDS]). ■ Rates of favourable outcomes and intracranial haemorrhage comparable with those in randomised trials can be achieved in routine clinical practice; however, translation of net benefit from tPA therapy requires organised and coordinated stroke management across the continuum of care. ■ Prerequisites for well organised and coordinated acute stroke care are: consensus among care providers on the use of tPA; stroke-care teams spanning the gaps between pre-hospital care, emergency departments and stroke units; and collegiate relations and effective communication networks between care providers.

AB - ■ Systematic reviews of randomised trials of tPA in acute ischaemic stroke indicate a clear benefit of treating selected patients within 3 hours of stroke onset. Moreover, a net benefit remained after adjustment for chance baseline imbalances between subgroups in stroke severity within one of these trials (National Institute of Neurological Disorders and Stroke [NINDS]). ■ Rates of favourable outcomes and intracranial haemorrhage comparable with those in randomised trials can be achieved in routine clinical practice; however, translation of net benefit from tPA therapy requires organised and coordinated stroke management across the continuum of care. ■ Prerequisites for well organised and coordinated acute stroke care are: consensus among care providers on the use of tPA; stroke-care teams spanning the gaps between pre-hospital care, emergency departments and stroke units; and collegiate relations and effective communication networks between care providers.

UR - http://www.scopus.com/inward/record.url?scp=3042814549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042814549&partnerID=8YFLogxK

U2 - 10.5694/j.1326-5377.2004.tb06127.x

DO - 10.5694/j.1326-5377.2004.tb06127.x

M3 - Review article

C2 - 15200362

AN - SCOPUS:3042814549

SN - 0025-729X

VL - 180

SP - 634

EP - 636

JO - Medical Journal of Australia

JF - Medical Journal of Australia

IS - 12

ER -

Tissue plasminogen activator (tPA) in acute ischaemic stroke: Time for collegiate communication and consensus

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this