Time to dP/dt(max) reflects both inotropic and chronotropic properties of cardiac contraction: A conscious dog study

David Adler, Srdjan D. Nikolic, Octavio Pajaro, Edmund H. Sonnenblick, Edward L. Yellin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

This study supports a mathematical model and previous findings indicating that t(d), the time from onset of contraction to dP/dt(max), reflects the time-dependent aspects of contraction and hence decreases with increasing contractility. Combined data from 20 conscious instrumented dogs create a highly significant inverse and linear t(d)-HR (heart rate) relation. Both norepinephrine and isoproterenol decreased t(d) values, but norepinephrine, in contrast to isoproterenol, decreased the heart rate by a reflex response. Despite the remarkable decline in heart rate (25.8%) t(d) was decreased (16.5%). During wide spontaneous R-R variations longer preceding intervals gave shorter t(d) values. The latter two facts indicate the dependence of t(d) on the contractile state rather than it being merely interval dependent.

Original languageEnglish (US)
Pages (from-to)287-295
Number of pages9
JournalPhysiological Measurement
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1996

Keywords

  • Cardiac chronotropism
  • Cardiac inotropism
  • Heart contractility
  • Left ventricular function
  • Myocardial contraction

ASJC Scopus subject areas

  • Biophysics
  • Physiology
  • Biomedical Engineering
  • Physiology (medical)

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