Time course and extent of recovery of endothelium-dependent contractions and relaxations after direct arterial injury

R. Cartier, P. J. Pearson, P. J. Lin, Hartzell V Schaff

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

To determine the time course of the return of endothelium-dependent relaxations and contractions during intimal regeneration, we performed balloon endothelial denudation of the thoracic and abdominal aorta of male Lewis rats and examined smooth muscle function and endothelium-dependent responses in vitro at 1, 2, 4, and 8 weeks after aortic injury. At each study interval during endothelial cell regeneration, vascular smooth muscle contracted and relaxed normally to direct stimulation with norepinephrine and sodium nitroprusside. Endothelium-dependent contractions to serotonin returned to normal at 1 week and developed into a hypercontractile response at 8 weeks. Endothelium-dependent relaxations to acetylcholine returned to normal at 8 weeks, but endothelium-dependent relaxations to adenosine diphosphate remained impaired. These experiments demonstrate that regenerating endothelium regains the ability to produce contracting factor before relaxing factor, and it even exhibits potentiated contractile activity 8 weeks after injury. Thus, after direct arterial injury, regenerating endothelium has abnormal endothelium-dependent function that predisposes the vessel to vasospasm and thrombosis.

Original languageEnglish (US)
Pages (from-to)371-377
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Volume102
Issue number3
StatePublished - 1991

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Endothelium
Wounds and Injuries
Regeneration
Tunica Intima
Abdominal Aorta
Nitroprusside
Thoracic Aorta
Vascular Smooth Muscle
Adenosine Diphosphate
Acetylcholine
Smooth Muscle
Serotonin
Norepinephrine
Thrombosis
Endothelial Cells

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Time course and extent of recovery of endothelium-dependent contractions and relaxations after direct arterial injury. / Cartier, R.; Pearson, P. J.; Lin, P. J.; Schaff, Hartzell V.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 102, No. 3, 1991, p. 371-377.

Research output: Contribution to journalArticle

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