Abstract
The clinical features of thymic carcinoid (TC) and bronchial carcinoid (BC) tumors as part of multiple endocrine neoplasia type 1 (MEN1) have been rarely described and their importance in clinical practice is debated. The objective of this study was to describe the clinical presentation and outcome of this uncommon manifestation of MEN1 in a tertiary care center setting. We present the clinical features of patients with MEN1 and either TC or BC evaluated at the Mayo Clinic from 1977 to 2013. A total of 348 patients with MEN1 were evaluated and the prevalence of TC was 2.0 % (n = 7) and of BC 4.9 % (n = 17). The majority of the patients with BC were men (61 %) diagnosed on routine screening (77 %) and BC was not the confirmed cause of death in any patient. In contrast, TC patients were all men and during follow-up 43 % died due to TC complications. We conclude that TC and BC tumors are uncommon, but important components of MEN1. BC were most commonly diagnosed during routine screening and associated with an indolent course. TC were predominantly seen in men and associated with a more aggressive behavior.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 247-253 |
| Number of pages | 7 |
| Journal | Hormones and Cancer |
| Volume | 6 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - Jun 13 2015 |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Endocrine and Autonomic Systems
Cite this
Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1 : The Mayo Clinic Experience from 1977 to 2013. / Singh Ospina, Naykky; Thompson, Geoffrey B.; C. Nichols, Francis; D. Cassivi, Stephen; Young, William Francis.
In: Hormones and Cancer, Vol. 6, No. 5-6, 13.06.2015, p. 247-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1
T2 - The Mayo Clinic Experience from 1977 to 2013
AU - Singh Ospina, Naykky
AU - Thompson, Geoffrey B.
AU - C. Nichols, Francis
AU - D. Cassivi, Stephen
AU - Young, William Francis
PY - 2015/6/13
Y1 - 2015/6/13
N2 - The clinical features of thymic carcinoid (TC) and bronchial carcinoid (BC) tumors as part of multiple endocrine neoplasia type 1 (MEN1) have been rarely described and their importance in clinical practice is debated. The objective of this study was to describe the clinical presentation and outcome of this uncommon manifestation of MEN1 in a tertiary care center setting. We present the clinical features of patients with MEN1 and either TC or BC evaluated at the Mayo Clinic from 1977 to 2013. A total of 348 patients with MEN1 were evaluated and the prevalence of TC was 2.0 % (n = 7) and of BC 4.9 % (n = 17). The majority of the patients with BC were men (61 %) diagnosed on routine screening (77 %) and BC was not the confirmed cause of death in any patient. In contrast, TC patients were all men and during follow-up 43 % died due to TC complications. We conclude that TC and BC tumors are uncommon, but important components of MEN1. BC were most commonly diagnosed during routine screening and associated with an indolent course. TC were predominantly seen in men and associated with a more aggressive behavior.
AB - The clinical features of thymic carcinoid (TC) and bronchial carcinoid (BC) tumors as part of multiple endocrine neoplasia type 1 (MEN1) have been rarely described and their importance in clinical practice is debated. The objective of this study was to describe the clinical presentation and outcome of this uncommon manifestation of MEN1 in a tertiary care center setting. We present the clinical features of patients with MEN1 and either TC or BC evaluated at the Mayo Clinic from 1977 to 2013. A total of 348 patients with MEN1 were evaluated and the prevalence of TC was 2.0 % (n = 7) and of BC 4.9 % (n = 17). The majority of the patients with BC were men (61 %) diagnosed on routine screening (77 %) and BC was not the confirmed cause of death in any patient. In contrast, TC patients were all men and during follow-up 43 % died due to TC complications. We conclude that TC and BC tumors are uncommon, but important components of MEN1. BC were most commonly diagnosed during routine screening and associated with an indolent course. TC were predominantly seen in men and associated with a more aggressive behavior.
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U2 - 10.1007/s12672-015-0228-z
DO - 10.1007/s12672-015-0228-z
M3 - Article
C2 - 26070346
AN - SCOPUS:84946490013
VL - 6
SP - 247
EP - 253
JO - Hormones and Cancer
JF - Hormones and Cancer
SN - 1868-8497
IS - 5-6
ER -