Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1: The Mayo Clinic Experience from 1977 to 2013

Naykky Singh Ospina, Geoffrey B. Thompson, Francis C. Nichols, Stephen D. Cassivi, William Francis Young

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The clinical features of thymic carcinoid (TC) and bronchial carcinoid (BC) tumors as part of multiple endocrine neoplasia type 1 (MEN1) have been rarely described and their importance in clinical practice is debated. The objective of this study was to describe the clinical presentation and outcome of this uncommon manifestation of MEN1 in a tertiary care center setting. We present the clinical features of patients with MEN1 and either TC or BC evaluated at the Mayo Clinic from 1977 to 2013. A total of 348 patients with MEN1 were evaluated and the prevalence of TC was 2.0 % (n = 7) and of BC 4.9 % (n = 17). The majority of the patients with BC were men (61 %) diagnosed on routine screening (77 %) and BC was not the confirmed cause of death in any patient. In contrast, TC patients were all men and during follow-up 43 % died due to TC complications. We conclude that TC and BC tumors are uncommon, but important components of MEN1. BC were most commonly diagnosed during routine screening and associated with an indolent course. TC were predominantly seen in men and associated with a more aggressive behavior.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalHormones and Cancer
Volume6
Issue number5-6
DOIs
StatePublished - Jun 13 2015

Fingerprint

Multiple Endocrine Neoplasia Type 1
Carcinoid Tumor
Tertiary Care Centers

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems

Cite this

Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1 : The Mayo Clinic Experience from 1977 to 2013. / Singh Ospina, Naykky; Thompson, Geoffrey B.; C. Nichols, Francis; D. Cassivi, Stephen; Young, William Francis.

In: Hormones and Cancer, Vol. 6, No. 5-6, 13.06.2015, p. 247-253.

Research output: Contribution to journalArticle

Singh Ospina, Naykky ; Thompson, Geoffrey B. ; C. Nichols, Francis ; D. Cassivi, Stephen ; Young, William Francis. / Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1 : The Mayo Clinic Experience from 1977 to 2013. In: Hormones and Cancer. 2015 ; Vol. 6, No. 5-6. pp. 247-253.
@article{89755e82ea4946cebaa2bff7d906598e,
title = "Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1: The Mayo Clinic Experience from 1977 to 2013",
abstract = "The clinical features of thymic carcinoid (TC) and bronchial carcinoid (BC) tumors as part of multiple endocrine neoplasia type 1 (MEN1) have been rarely described and their importance in clinical practice is debated. The objective of this study was to describe the clinical presentation and outcome of this uncommon manifestation of MEN1 in a tertiary care center setting. We present the clinical features of patients with MEN1 and either TC or BC evaluated at the Mayo Clinic from 1977 to 2013. A total of 348 patients with MEN1 were evaluated and the prevalence of TC was 2.0 {\%} (n = 7) and of BC 4.9 {\%} (n = 17). The majority of the patients with BC were men (61 {\%}) diagnosed on routine screening (77 {\%}) and BC was not the confirmed cause of death in any patient. In contrast, TC patients were all men and during follow-up 43 {\%} died due to TC complications. We conclude that TC and BC tumors are uncommon, but important components of MEN1. BC were most commonly diagnosed during routine screening and associated with an indolent course. TC were predominantly seen in men and associated with a more aggressive behavior.",
author = "{Singh Ospina}, Naykky and Thompson, {Geoffrey B.} and {C. Nichols}, Francis and {D. Cassivi}, Stephen and Young, {William Francis}",
year = "2015",
month = "6",
day = "13",
doi = "10.1007/s12672-015-0228-z",
language = "English (US)",
volume = "6",
pages = "247--253",
journal = "Hormones and Cancer",
issn = "1868-8497",
publisher = "Springer US",
number = "5-6",

}

TY - JOUR

T1 - Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1

T2 - The Mayo Clinic Experience from 1977 to 2013

AU - Singh Ospina, Naykky

AU - Thompson, Geoffrey B.

AU - C. Nichols, Francis

AU - D. Cassivi, Stephen

AU - Young, William Francis

PY - 2015/6/13

Y1 - 2015/6/13

N2 - The clinical features of thymic carcinoid (TC) and bronchial carcinoid (BC) tumors as part of multiple endocrine neoplasia type 1 (MEN1) have been rarely described and their importance in clinical practice is debated. The objective of this study was to describe the clinical presentation and outcome of this uncommon manifestation of MEN1 in a tertiary care center setting. We present the clinical features of patients with MEN1 and either TC or BC evaluated at the Mayo Clinic from 1977 to 2013. A total of 348 patients with MEN1 were evaluated and the prevalence of TC was 2.0 % (n = 7) and of BC 4.9 % (n = 17). The majority of the patients with BC were men (61 %) diagnosed on routine screening (77 %) and BC was not the confirmed cause of death in any patient. In contrast, TC patients were all men and during follow-up 43 % died due to TC complications. We conclude that TC and BC tumors are uncommon, but important components of MEN1. BC were most commonly diagnosed during routine screening and associated with an indolent course. TC were predominantly seen in men and associated with a more aggressive behavior.

AB - The clinical features of thymic carcinoid (TC) and bronchial carcinoid (BC) tumors as part of multiple endocrine neoplasia type 1 (MEN1) have been rarely described and their importance in clinical practice is debated. The objective of this study was to describe the clinical presentation and outcome of this uncommon manifestation of MEN1 in a tertiary care center setting. We present the clinical features of patients with MEN1 and either TC or BC evaluated at the Mayo Clinic from 1977 to 2013. A total of 348 patients with MEN1 were evaluated and the prevalence of TC was 2.0 % (n = 7) and of BC 4.9 % (n = 17). The majority of the patients with BC were men (61 %) diagnosed on routine screening (77 %) and BC was not the confirmed cause of death in any patient. In contrast, TC patients were all men and during follow-up 43 % died due to TC complications. We conclude that TC and BC tumors are uncommon, but important components of MEN1. BC were most commonly diagnosed during routine screening and associated with an indolent course. TC were predominantly seen in men and associated with a more aggressive behavior.

UR - http://www.scopus.com/inward/record.url?scp=84946490013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946490013&partnerID=8YFLogxK

U2 - 10.1007/s12672-015-0228-z

DO - 10.1007/s12672-015-0228-z

M3 - Article

C2 - 26070346

AN - SCOPUS:84946490013

VL - 6

SP - 247

EP - 253

JO - Hormones and Cancer

JF - Hormones and Cancer

SN - 1868-8497

IS - 5-6

ER -