Thrombolysis with systemically administered t-PA in a new venous thrombosis model

Richard E Hayden, Patrick W. McLear, John G. Phillips, Steven M. Dawson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Early thrombosis of either the arterial or venous supply of a free flap or island pedicle flap results in total flap necrosis. Until very recently, the only option for flap salvage was surgical intervention and, often, revision of the vascular pedicle. Current advances in the pharmacologic treatment of coronary artery and deep leg vein thrombosis have kindled interest in the field of reconstructive surgery for pharmacologic treatment of thromboses that compromise flaps. In the past, there has been research on the local and systemic administration of thrombolytic agents for lysis of experimentally induced thrombi in various animal models. A new venous inversion graft thrombosis model is presented here, which possesses many advantages over previously employed research models. This study demonstrates thrombolysis with systemically administered tissue plasminogen activator (t-PA) in this model.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalLaryngoscope
Volume99
Issue number1
StatePublished - 1989
Externally publishedYes

Fingerprint

Tissue Plasminogen Activator
Venous Thrombosis
Thrombosis
Reconstructive Surgical Procedures
Surgical Flaps
Fibrinolytic Agents
Free Tissue Flaps
Research
Blood Vessels
Leg
Coronary Vessels
Necrosis
Animal Models
Transplants

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Hayden, R. E., McLear, P. W., Phillips, J. G., & Dawson, S. M. (1989). Thrombolysis with systemically administered t-PA in a new venous thrombosis model. Laryngoscope, 99(1), 100-104.

Thrombolysis with systemically administered t-PA in a new venous thrombosis model. / Hayden, Richard E; McLear, Patrick W.; Phillips, John G.; Dawson, Steven M.

In: Laryngoscope, Vol. 99, No. 1, 1989, p. 100-104.

Research output: Contribution to journalArticle

Hayden, RE, McLear, PW, Phillips, JG & Dawson, SM 1989, 'Thrombolysis with systemically administered t-PA in a new venous thrombosis model', Laryngoscope, vol. 99, no. 1, pp. 100-104.
Hayden, Richard E ; McLear, Patrick W. ; Phillips, John G. ; Dawson, Steven M. / Thrombolysis with systemically administered t-PA in a new venous thrombosis model. In: Laryngoscope. 1989 ; Vol. 99, No. 1. pp. 100-104.
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