Thrombin binding to human brain and spinal cord

M. McKinney, R. M. Snider, E. Richelson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Thrombin, a serine protease that regulates hemostasis, has been shown to stimulate the formation of cGMP in murine neuroblastoma cells. The nervous system in vivo thus may be postulated to respond to this blood-borne factor after it breaches the blood-brain barrier, as in trauma. Human α-thrombin was radiolabeled with 125I and shown to bind rapidly, reversibly, and with high affinity to human brain and spinal cord. These findings indicate the presence of specific thrombin-binding sites in nervous tissue and may have important clinical implications.

Original languageEnglish (US)
Pages (from-to)829-831
Number of pages3
JournalMayo Clinic Proceedings
Volume58
Issue number12
StatePublished - 1983

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Thrombin
Spinal Cord
Brain
Nerve Tissue
Serine Proteases
Hemostasis
Blood-Brain Barrier
Neuroblastoma
Nervous System
Binding Sites
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

McKinney, M., Snider, R. M., & Richelson, E. (1983). Thrombin binding to human brain and spinal cord. Mayo Clinic Proceedings, 58(12), 829-831.

Thrombin binding to human brain and spinal cord. / McKinney, M.; Snider, R. M.; Richelson, E.

In: Mayo Clinic Proceedings, Vol. 58, No. 12, 1983, p. 829-831.

Research output: Contribution to journalArticle

McKinney, M, Snider, RM & Richelson, E 1983, 'Thrombin binding to human brain and spinal cord', Mayo Clinic Proceedings, vol. 58, no. 12, pp. 829-831.
McKinney M, Snider RM, Richelson E. Thrombin binding to human brain and spinal cord. Mayo Clinic Proceedings. 1983;58(12):829-831.
McKinney, M. ; Snider, R. M. ; Richelson, E. / Thrombin binding to human brain and spinal cord. In: Mayo Clinic Proceedings. 1983 ; Vol. 58, No. 12. pp. 829-831.
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